A male patient of 20 years of age with clinical features of hypogonadism presented high LH, low T and normal FSH blood level. Although the LH data suggested a primary gonadal effect. he responded normally to hCG administration, with a rise of plasma testosterone. During therapeutical adminisratioin of hCG he also improved clinically. Thus, the patient's Leydig cells responded to exogenous hCG but not to endogenous LH. This syndrome is likely to be attributable to the presence of an immunologically active but biologically inactive LH molecule.
Male hypogonadism associated with elevated LH, normal FSH and low Testosterone possibly due to an abnormal LH molecule.
VICARI, Enzo Saretto;
1979-01-01
Abstract
A male patient of 20 years of age with clinical features of hypogonadism presented high LH, low T and normal FSH blood level. Although the LH data suggested a primary gonadal effect. he responded normally to hCG administration, with a rise of plasma testosterone. During therapeutical adminisratioin of hCG he also improved clinically. Thus, the patient's Leydig cells responded to exogenous hCG but not to endogenous LH. This syndrome is likely to be attributable to the presence of an immunologically active but biologically inactive LH molecule.File in questo prodotto:
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