Differential scanning calorimetry has been used to investigate the thermotropic behavior of DPPC liposomes in the presence of different amounts of retinoids in a study of the sites concerned in the mutual lipid-retinoid interaction. The perturbing effect of retinal and retinol on DPPC liposome gel-liquid crystal phase transition has been related to the difference in the polar end group of retinoid. The hydrophilic polar group prevalence over the apolar tail has been evidentiated. Membrane fluidity increases by increasing the retinoid amount. These liposomes displayed a phase separation at high retinal or retinol concentrations
THERMOTROPIC BEHAVIOR OF DIPALMITOYLPHOSPHATIDYLCHOLINE LIPOSOMES CONTAINING RETINOIDS
CASTELLI, Francesco
1987-01-01
Abstract
Differential scanning calorimetry has been used to investigate the thermotropic behavior of DPPC liposomes in the presence of different amounts of retinoids in a study of the sites concerned in the mutual lipid-retinoid interaction. The perturbing effect of retinal and retinol on DPPC liposome gel-liquid crystal phase transition has been related to the difference in the polar end group of retinoid. The hydrophilic polar group prevalence over the apolar tail has been evidentiated. Membrane fluidity increases by increasing the retinoid amount. These liposomes displayed a phase separation at high retinal or retinol concentrationsFile in questo prodotto:
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