Pigs are currently the preferred species for future organ xenotransplantation.With advances in the development of genetically modified pigs, clinicalxenotransplantation is becoming closer to reality. In preclinical studies(pig-to-nonhuman primate), the xenotransplantation of livers from pigs transgenicfor human CD55 or from α1,3-galactosyltransferase gene-knockout pigs+/-transgenic for human CD46, is associated with survival of approximately 7-9 days.Although hepatic function, including coagulation, has proved to be satisfactory, the immediate development of thrombocytopenia is very limiting for pig liverxenotransplantation even as a 'bridge' to allotransplantation. Current studiesare directed to understand the immunobiology of platelet activation, aggregation and phagocytosis, in particular the interaction between platelets and liversinusoidal endothelial cells, hepatocytes and Kupffer cells, toward identifyinginterventions that may enable clinical application.
Immunobiology of liver xenotransplantation
VEROUX, Massimiliano;
2012-01-01
Abstract
Pigs are currently the preferred species for future organ xenotransplantation.With advances in the development of genetically modified pigs, clinicalxenotransplantation is becoming closer to reality. In preclinical studies(pig-to-nonhuman primate), the xenotransplantation of livers from pigs transgenicfor human CD55 or from α1,3-galactosyltransferase gene-knockout pigs+/-transgenic for human CD46, is associated with survival of approximately 7-9 days.Although hepatic function, including coagulation, has proved to be satisfactory, the immediate development of thrombocytopenia is very limiting for pig liverxenotransplantation even as a 'bridge' to allotransplantation. Current studiesare directed to understand the immunobiology of platelet activation, aggregation and phagocytosis, in particular the interaction between platelets and liversinusoidal endothelial cells, hepatocytes and Kupffer cells, toward identifyinginterventions that may enable clinical application.File | Dimensione | Formato | |
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