Tolerability and clinical efficacy of desmin in the treatment of superficial thrombovaricophlebitis

Angiology. 1996 Sep;47(9):887-94. Tolerability and clinical efficacy of desmin in the treatment of superficial thrombovaricophlebitis. Andreozzi GM, Signorelli S, Di Pino L, Martini R, Marchitelli E, Pinto A, Romeo S, Zamboni V, Palazzini E. Source Chair of Angiology, A. Francaviglia, University of Catania, Italy. Abstract Fifty-six patients with superficial thrombovaricophlebitis of the lower limbs were enrolled in an open and multicenter (4 centers) trial for a period of thirty days. Patients were randomly allocated to three treatment groups to receive a new low-molecular-weight dermatan sulfate (Desmin) at the dose, respectively, of 100 mg once daily by subcutaneous (SC) route, 100 mg twice a day SC, and 200 mg once daily by intramuscular (IM) route. The general and local tolerability and the clinical efficacy of the drug were evaluated by means of clinical, instrumental, and laboratory parameters. Desmin proved capable of effectively improving the symptoms of patients affected by thrombovaricophlebitis, inducing rapid regression by the tenth day of treatment. The daily dose of 200 mg (either SC or IM) was more effective than the 100 mg dose. The systemic tolerability of the drug, administered for the first time for one month, was extremely good, without significant variations in the relevant laboratory tests. Local tolerance (at the site of injection) of the drug was also good. PMID: 8810655 [PubMed - indexed for MEDLINE]