Cisapride is a prokinetic agent used to treat gastrointestinal motility disorders. This drug restores, normalizes, and facilitates smooth muscle function from the esophagus to the colon without antidopaminergic effects. To evaluate the effects of cisapride on prolactin, blood ammonia, stool frequency, and degree of hepatic encephalopathy, 10 patients with cirrhosis and 10 healthy controls were treated with the drug for 10 days. Cisapride increased stool frequency and did not modify prolactin and blood ammonia levels. The drug was well tolerated. Cisapride's favorable effects on dyspepsia and gastrointestinal motility can improve the treatment of patients with chronic liver disease.
Effects of Cisapride on blood ammonia and prolactin in patients with cirrhosis
TROVATO, Guglielmo;CATALANO, Daniela;
1993-01-01
Abstract
Cisapride is a prokinetic agent used to treat gastrointestinal motility disorders. This drug restores, normalizes, and facilitates smooth muscle function from the esophagus to the colon without antidopaminergic effects. To evaluate the effects of cisapride on prolactin, blood ammonia, stool frequency, and degree of hepatic encephalopathy, 10 patients with cirrhosis and 10 healthy controls were treated with the drug for 10 days. Cisapride increased stool frequency and did not modify prolactin and blood ammonia levels. The drug was well tolerated. Cisapride's favorable effects on dyspepsia and gastrointestinal motility can improve the treatment of patients with chronic liver disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
