BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is mostly related toincreased BMI and sedentary life, even if it not directly attributable only to these or to single specific factors. Unhealthy lifestyle and obesity are the most probable causes, also in non-diabetic and without alcohol abuse patients, even iflean individuals can be involved. NAFLD treatment is currently warranted anddriven by comprehensive lifestyle intervention, a valuable objective that is more often wished for than actually achieved. The aim is to re-assess the effectiveness of an intervention focused to increase the Adherence toMediterranean Diet Score (AMDS) and the level of physical exercise, investigatingthe factors associated with failure and reporting the time that must elapsebefore such intervention becomes effective.METHODS: The study included 90 (F 46, M 44) non-alcoholic non-diabetic patients, aged 50.13 ± 13.68 years, BMI 31.01 ± 5.18 with evidence of fatty liver by ultrasound.RESULTS: A significant decrease of Bright Liver Score (BLS) was observed onlyafter 6 months of intervention: differently, at the first and third month ofmonitoring fatty liver changes were still not significant. By a multiple linearregression model Adherence to Mediterranean Diet change (p:0.015) and body massindex changes (p:<0.0001) independently explain the variance of decrease of fattyliver involvement (R2 = 0.519; p < 0.0001).CONCLUSION: Adherence to Mediterranean Diet is a significant predictor of changes in the fat content of the liver in overweight patients with NAFLD. The effect of the diet is gradual and favorable and it is independent of other lifestylechanges.
|Titolo:||Mediterranean diet and non-alcoholic fatty liver disease.: The need of extended and comprehensive interventions.|
|Data di pubblicazione:||2014|
|Appare nelle tipologie:||1.1 Articolo in rivista|