Background: Hepatitis C virus infection and interferon treatment are often associated with anxiety, depressivesymptoms and poor health-related quality of life.To evaluate the Silybin-vitamin E-phospholipids complex effect on work ability and whether health related factors(anxiety and depression) were associated with work ability in subjects with chronic hepatitis C treated with Pegylated-Interferon-α2b (Peg–IFN) and Ribavirin (RBV).Methods: Thirty-one patients (Group A) with chronic hepatitis and other 31 subjects in Group B were recruited in a randomized, prospective, placebo controlled, double blind clinical trial. Group A received 1.5 mg/kg per weekof Peg–IFN plus RBV and placebo, while Group B received the same dosage of Peg–IFN plus RBV plus association of Silybin 94 mg + vitamin E 30 mg + phospholipids 194 mg in pills for 12 months. All subjects underwent to laboratory exams and questionnaires to evaluate depression (Beck Depression Inventory - BDI), anxiety (State-trait anxiety inventory - STAI) and work ability (Work ability Index - WAI).Results: The comparison between group A and group B showed significant differences after 6 months in ALT (P < 0.001),and viremia (P < 0.05), after 12 months in ALT (P < 0.001), and AST (P < 0.001), at follow up in AST (P < 0.05), and ALT (P < 0.001). Significant difference were observed after 1 month in WAI (p < 0.001) and BDI (P < 0.05), after6 months in WAI (P < 0.05) and STAI (P < 0.05), after 12 months and at follow up in WAI, STAI and BDI (p < 0.01).Conclusions: The supplementation with Silybin-vitamin E -phospholipids complex increased work ability andreduced depression and anxiety in patients treated with Peg–IFN and RBV.
|Titolo:||Silybin supplementation during HCV therapy with pegylated interferon-α plus ribavirin reduces depression and anxiety and increases work ability|
|Autori interni:||BERTINO, Gaetano|
|Data di pubblicazione:||2016|
|Appare nelle tipologie:||1.1 Articolo in rivista|