Floret-like multinucleated giant cells in a neurofibroma from a patient with NF1: an unusual finding for such a tumor

We read with interest the article by Damiani and Eusebi dealing with the occurrence of multinucleated giant cells in gynecomastia from two patients with type 1 neurofibromatosis (NF1). We observed a case of cutaneous neurofibroma in a 52-year-old man affected by NF1, showing numerous floretlike multinucleated giant cells (FMGCs) similar to those described by Damiani and Eusebi. To the best of our knowledge, FMGCs have not been previously reported in neurofibroma.Notwithstanding these diagnostic considerations, the detection of FMGCs in a neurofibroma from a patient with NF1 is an intriguing finding when we remember that similar cells have been described in gynecomastia in four patients with this genetic disorder. We advise searching for FMGCs in tissues from patients with NF1 to establish if they are typical or only an occasional finding.