Aging is a common risk factor for neurodegenerative diseases. The free radical theory of aging states that functional impairments are due to the reaction of critical cellular components with free radicals, reactive oxygen species (ROS), and reactive nitrogen species (RNS). We examine the formation of major ROS (O-2(-), HO., HOCl, and H2O2) and RNS (NO, ONOO-, and NO2). We then examine two endogenous antioxidants systems (glutathione and heat-shock proteins) that are decreased in age-related neurodegenerative disorders. Finally, we review the evidence of age-related, free radical-mediated damage to the brain, emphasizing lipid peroxidation and protein oxidation. We conclude that free radical-mediated lipid peroxidation and protein oxidation are at least partially responsible for the deterioration of the central nervous system in aging
Free radicals and brain aging
CALABRESE, Vittorio;
2004-01-01
Abstract
Aging is a common risk factor for neurodegenerative diseases. The free radical theory of aging states that functional impairments are due to the reaction of critical cellular components with free radicals, reactive oxygen species (ROS), and reactive nitrogen species (RNS). We examine the formation of major ROS (O-2(-), HO., HOCl, and H2O2) and RNS (NO, ONOO-, and NO2). We then examine two endogenous antioxidants systems (glutathione and heat-shock proteins) that are decreased in age-related neurodegenerative disorders. Finally, we review the evidence of age-related, free radical-mediated damage to the brain, emphasizing lipid peroxidation and protein oxidation. We conclude that free radical-mediated lipid peroxidation and protein oxidation are at least partially responsible for the deterioration of the central nervous system in agingI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
