The differences in complexation behaviour of two diastereomeric tetraazamacrocycles, meso (1) and racemic (2) 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane, are explained by different conformations in solution, 1 being one stable conformer of almost rigid structure while 2 shows higher conformational flexibility to avoid steric strain, The methods used were H-1 and C-13 NMR and molecular modelling.
APPROACH TO THE CONFORMATIONAL BEHAVIOR OF TETRAAZAMACROCYCLES IN THE SOLUTION-STATE - NMR AND MOLECULAR MODELING STUDIES
FAILLA, Salvatore;
1995-01-01
Abstract
The differences in complexation behaviour of two diastereomeric tetraazamacrocycles, meso (1) and racemic (2) 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane, are explained by different conformations in solution, 1 being one stable conformer of almost rigid structure while 2 shows higher conformational flexibility to avoid steric strain, The methods used were H-1 and C-13 NMR and molecular modelling.File in questo prodotto:
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