Summary Basal levels of oxidants are indispensible for redox signaling to produce adaptive cellular responses such as vitagenes linked to cell survival, but at higher levels are detrimental to cells, contributing to aging and to the pathogenesis of numerous age-related diseases. Aging is a complex systemic process and the major gap in ageing research remains the insufficient knowledge about pathways shifting from normal “healthy” aging to disease-associated pathological aging. The major complication of normal “healthy” aging is in fact the increasing risk for age-related diseases such as cardiovascular diseases, diabetes mellitus and neurodegenerative pathologies that can adversely affect the quality of life in general, with enhanced incidence of co-morbidities and mortality. In this context global “omics” approaches may help to dissect and fully study cellular and molecular mechanisms of aging and age-associated processes. The proteome, being more close to the phenotype than transcriptome and more stable than the metabolome, represents the most promising “omics” field in aging research. In the present study we exploit recent advances in the redox biology of aging and discuss the potential of proteomics approaches as innovative tools for monitoring at the proteome level the extent of protein oxidative insult and related modifications with identification of targeted proteins.
|Titolo:||analitical approaches to the diagnosis and treatment of aging and age related disease :redox status and proteomics|
|Data di pubblicazione:||2015|
|Appare nelle tipologie:||1.1 Articolo in rivista|