There are several causes of hepatocellular carcinoma (HCC), but certainly the hepatitis C virus (HCV) is one of the most common. The HCV is able to contribute, both directly and indirectly, to the development of HCC. Determining early HCV clearance before an advanced liver disease develops, is absolutely necessary as this prevents the initiation of the cascade of events induced by HCV that may result in the development of HCC. The early treatment of the infection and the clearance of HCV represents today, in the age of the direct antiviral agents (DAAs), an extraordinary opportunity for true prevention of the development of HCV-related HCC.

Responsibility of hepatitis C virus in the development of hepatocellular carcinoma: From molecular alterations to possible solutions

Bertino, Gaetano
Conceptualization
;
Malaguarnera, Giulia
Membro del Collaboration Group
;
Frazzetto, Evelise
Membro del Collaboration Group
;
SCIUTO, ALICE
Membro del Collaboration Group
;
Inserra, Gaetano
Membro del Collaboration Group
;
Zanghì, Guido Nicola
Membro del Collaboration Group
;
Malaguarnera, Michele
Membro del Collaboration Group
2018-01-01

Abstract

There are several causes of hepatocellular carcinoma (HCC), but certainly the hepatitis C virus (HCV) is one of the most common. The HCV is able to contribute, both directly and indirectly, to the development of HCC. Determining early HCV clearance before an advanced liver disease develops, is absolutely necessary as this prevents the initiation of the cascade of events induced by HCV that may result in the development of HCC. The early treatment of the infection and the clearance of HCV represents today, in the age of the direct antiviral agents (DAAs), an extraordinary opportunity for true prevention of the development of HCV-related HCC.
2018
Hepatitis C virus; Hepatocellular carcinoma; Inflammation; Fibrosis; Insulin-resistance; Oxidative stress; Direct acting antivirals
File in questo prodotto:
File Dimensione Formato  
Bertino G WJH-10-448 2018.pdf

accesso aperto

Tipologia: Versione Editoriale (PDF)
Dimensione 1.03 MB
Formato Adobe PDF
1.03 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/329731
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 5
social impact