Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.

Ifosfamide and vinorelbine: An active regimen for patients with relapsed or refractory Hodgkin's disease

Soto Parra H.;
1998-01-01

Abstract

Twenty-six patients with relapsed or refractory Hodgkin's disease (HD) were treated with an intensive salvage regimen combining ifosfamide (3000 mg/m2/d, days 1-4 through continuous intravenous infusion) and vinorelbine (25 mg/m2, i.v. days 1 and 5) with mesna uroprotection and G-CSF support. Courses were given at 3-week intervals. Ten patients achieved a complete and 10 patients a partial response, yielding an overall response rate of 77%. The main toxic effect was neutropenia and the combination was well tolerated.
1998
Hodgkin's disease; Ifosfamide; Recurrent disease; Salvage therapy; Vinorelbine; Adult; Antineoplastic Combined Chemotherapy Protocols; Female; Hodgkin Disease; Humans; Ifosfamide; Male; Middle Aged; Neutropenia; Pilot Projects; Recurrence; Salvage Therapy; Treatment Outcome; Vinblastine; Vinorelbine
File in questo prodotto:
File Dimensione Formato  
Ifosfamide and vinorelbine.pdf

solo gestori archivio

Tipologia: Versione Editoriale (PDF)
Dimensione 233.57 kB
Formato Adobe PDF
233.57 kB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/369942
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 39
  • ???jsp.display-item.citation.isi??? 35
social impact