A 71-year-old woman presented with a rare case of malignant fibrous histiocytoma (MFH) associated with recurrent meningothelial meningioma. The neuroimaging findings were consistent with a diagnosis of recurrent meningioma. Surgical removal was performed. Histological and immunohistochemical examinations detected meningothelial and MFH tumor components. The MFH component showed diffuse 3+ staining for epidermal growth factor receptor protein, predominantly located on the cell membrane and to a lesser extent within the cytoplasm. However, a fluorescein isothiocyanate analysis detected no amplification of epidermal growth factor receptor gene.

Epidermal growth factor receptor overexpressed malignant fibrous histiocytoma associated with recurrent meningothelial meningioma

CALTABIANO, ROSARIO
Primo
;
LANZAFAME, Salvatore
2009-01-01

Abstract

A 71-year-old woman presented with a rare case of malignant fibrous histiocytoma (MFH) associated with recurrent meningothelial meningioma. The neuroimaging findings were consistent with a diagnosis of recurrent meningioma. Surgical removal was performed. Histological and immunohistochemical examinations detected meningothelial and MFH tumor components. The MFH component showed diffuse 3+ staining for epidermal growth factor receptor protein, predominantly located on the cell membrane and to a lesser extent within the cytoplasm. However, a fluorescein isothiocyanate analysis detected no amplification of epidermal growth factor receptor gene.
2009
malignant fibrous histiocytoma; meningioma; Epidermal growth factor receptor
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/4071
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