Recent studies suggest that subjects with hypothyroidism under therapy with L-T4 might develop oxidative stress. The aim of this study was to test a redox-balance modulator, FPP, together with subclinical (SH) or mild hypothyroidism (MH) treatment in view of biochemical changes. 60 females treated for SH-MH were divided into two matched groups and received either FPP 3gr 1 sachet t.i.d. or placebo for 3 months. A significant baseline increase of all oxidative markers was observed in SH-MH (p<0.05 vs control) and even more under T4 treatment (p<0.05). FPP caused a normalization of redox markers (p<0.01 vs placebo). Thyroid supplementation accelerates mitochondrial oxygen consumption and oxidative stress while a redox-modulator therapy is advisable, given the long-lasting treatment in such cases.

The Hidden Phenomenon of Oxidative Stress During Treatment of Subclinical-Mild Hypothyroidism: A Protective Nutraceutical Intervention

CATANZARO, Roberto;
2014-01-01

Abstract

Recent studies suggest that subjects with hypothyroidism under therapy with L-T4 might develop oxidative stress. The aim of this study was to test a redox-balance modulator, FPP, together with subclinical (SH) or mild hypothyroidism (MH) treatment in view of biochemical changes. 60 females treated for SH-MH were divided into two matched groups and received either FPP 3gr 1 sachet t.i.d. or placebo for 3 months. A significant baseline increase of all oxidative markers was observed in SH-MH (p<0.05 vs control) and even more under T4 treatment (p<0.05). FPP caused a normalization of redox markers (p<0.01 vs placebo). Thyroid supplementation accelerates mitochondrial oxygen consumption and oxidative stress while a redox-modulator therapy is advisable, given the long-lasting treatment in such cases.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/42519
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