Animals with learning and memory alterations induced by the intracerebroventricular administration of 6-hydroxydopamine or intraperitoneal injections of diazepam or buspirone were treated with L-α-glycerylphosphorylcholine (α-GPC) at the dose of 100 mg/kg/day for 20 days. The cognitive deficit, studied with the test of passive avoidance behavior, was recovered in all experimental groups. Motor activity tested with an open field was also increased by α-GPC. These results suggest that the mechanism of action of α-GPC involves, beside the cholinergic system, also other neurotransmitters in the brain.

EFFECTS OF L-A-GLYCERYL PHOSPHORYL CHOLINE ON DRUG-INDUCED BEHAVIORAL ALTERATIONS IN RATS

DRAGO, Filippo
;
D'AGATA, VELIA MARIA;
1992-01-01

Abstract

Animals with learning and memory alterations induced by the intracerebroventricular administration of 6-hydroxydopamine or intraperitoneal injections of diazepam or buspirone were treated with L-α-glycerylphosphorylcholine (α-GPC) at the dose of 100 mg/kg/day for 20 days. The cognitive deficit, studied with the test of passive avoidance behavior, was recovered in all experimental groups. Motor activity tested with an open field was also increased by α-GPC. These results suggest that the mechanism of action of α-GPC involves, beside the cholinergic system, also other neurotransmitters in the brain.
File in questo prodotto:
File Dimensione Formato  
art 27.pdf

solo gestori archivio

Tipologia: Versione Editoriale (PDF)
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 631.18 kB
Formato Adobe PDF
631.18 kB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/44717
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact