6-Thioguanine (6-TG) is being given to patients with Crohn's disease failing conventional immunosuppression, but cases of hepatotoxicity have been reported. We report the case of a patient who developed acute sinusoidal obstruction syndrome after 3 months of successful 6-TG treatment. A complete regression of liver injury was observed after withdrawal of 6-TG. Our case-report underscores the risk of hepatic injury due to the administration of 6-TG for Crohn's disease. We strongly recommend alternative therapeutic options in patients intolerant or resistant to conventional thiopurines.
Liver veno-occlusive disease (VOD) in a patient given 6-thioguanine for crohn's disease
MALATINO, Lorenzo
2014-01-01
Abstract
6-Thioguanine (6-TG) is being given to patients with Crohn's disease failing conventional immunosuppression, but cases of hepatotoxicity have been reported. We report the case of a patient who developed acute sinusoidal obstruction syndrome after 3 months of successful 6-TG treatment. A complete regression of liver injury was observed after withdrawal of 6-TG. Our case-report underscores the risk of hepatic injury due to the administration of 6-TG for Crohn's disease. We strongly recommend alternative therapeutic options in patients intolerant or resistant to conventional thiopurines.File in questo prodotto:
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