Introduction: The role of platelets (Ps) and platelet-derived microparticles (MPs) in venous thromboembolism (VTE) is still being debated.Methods: We measured MPs, velocity of thrombin formation (PiCT) and phospholipid generation (PLPs) in 40 patients with unprovoked deep vein thrombosis (DVT), who were compared with 40 healthy controls.Results: MPs were higher in DVT (7.12 nM; 25th-75th percentile 5.26-9.12) than in controls (5.45 nM; 25th-75th percentile 1.67-8.96) (p = 0.19). PiCT velocity was lower in DVT (1.87 sec; 25th-75th percentile 1.75-1.93 sec) compared with controls (1.95 sec; 25th-75th percentile 1.84-2.24 sec) (p = 0.04). PLPs were higher in DVT (77.03 mu g/mL; 25th-75th percentile 72.12-103.59 mu g/mL) compared with controls (68.65 mu g/mL, 25th-75th percentile 55.31-78.20 mu g/mL) (p = 0.02).Discussion: We hypothesize that MPs could be integrated with the lab network assay in evaluating Ps' role as an activated procoagulative condition. We encourage research on Ps and P-derived microvesicle pathways in patients with unprovoked DVT and not only in patients with cancer-induced DVT.

Platelet-Derived Microparticles (MPs) and Thrombin Generation Velocity in Deep Vein Thrombosis (DVT): Results of a Case-Control Study

Signorelli, Salvatore Santo;Oliveri Conti, Gea;Fiore, Maria;Zuccarello, Pietro;Gaudio, Agostino;Ferrante, Margherita
2020

Abstract

Introduction: The role of platelets (Ps) and platelet-derived microparticles (MPs) in venous thromboembolism (VTE) is still being debated.Methods: We measured MPs, velocity of thrombin formation (PiCT) and phospholipid generation (PLPs) in 40 patients with unprovoked deep vein thrombosis (DVT), who were compared with 40 healthy controls.Results: MPs were higher in DVT (7.12 nM; 25th-75th percentile 5.26-9.12) than in controls (5.45 nM; 25th-75th percentile 1.67-8.96) (p = 0.19). PiCT velocity was lower in DVT (1.87 sec; 25th-75th percentile 1.75-1.93 sec) compared with controls (1.95 sec; 25th-75th percentile 1.84-2.24 sec) (p = 0.04). PLPs were higher in DVT (77.03 mu g/mL; 25th-75th percentile 72.12-103.59 mu g/mL) compared with controls (68.65 mu g/mL, 25th-75th percentile 55.31-78.20 mu g/mL) (p = 0.02).Discussion: We hypothesize that MPs could be integrated with the lab network assay in evaluating Ps' role as an activated procoagulative condition. We encourage research on Ps and P-derived microvesicle pathways in patients with unprovoked DVT and not only in patients with cancer-induced DVT.
biomarkers
deep vein thrombosis
extracellular vesicles
microparticles
platelet
Aged
Biomarkers
Blood Coagulation Tests
Blood Platelets
Case-Control Studies
Cell-Derived Microparticles
Female
Humans
Kinetics
Male
Middle Aged
Phospholipids
Thrombin
Venous Thrombosis
Blood Coagulation
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/536898
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