To evaluate c-Met expression in human tooth germ development. An immunohistochemical study on c-Met expression in tooth germs of 8 human fetus between the 7th and 9th week. In the Bud stage C-Met immunopositivity was, moderately to strongly, detected both in the inner and the outer epithelium of the enamel organ. In particular, moderate staining was detected in a specific portion of tooth germs that corresponds to apical portion of the enamel organ. In the bell stage tooth germs were characterized by much stronger c-Met immunopositivity in cytoplasm, inner enamel epithelium, bilateral cusps and above all in the plasma apical membrane on the mesenchymal side. In conclusion because enamel organ cells can interact with mesenchymal cells directly, and c-Met is expressed in the stages at which mesenchymal induction is guided by the dental epithelium, it is conceivable that c-Met is related to tooth germ morphogenesis and cell differentiation.

Immunolocalization of hepatocyte growth factor receptor, c-Met, in human fetal tooth germ

LORETO, CARLA AGATA
Primo
;
MUSUMECI, GIUSEPPE
Secondo
;
CALTABIANO, ROSARIO;LEONARDI, Rosalia Maria
Ultimo
2009-01-01

Abstract

To evaluate c-Met expression in human tooth germ development. An immunohistochemical study on c-Met expression in tooth germs of 8 human fetus between the 7th and 9th week. In the Bud stage C-Met immunopositivity was, moderately to strongly, detected both in the inner and the outer epithelium of the enamel organ. In particular, moderate staining was detected in a specific portion of tooth germs that corresponds to apical portion of the enamel organ. In the bell stage tooth germs were characterized by much stronger c-Met immunopositivity in cytoplasm, inner enamel epithelium, bilateral cusps and above all in the plasma apical membrane on the mesenchymal side. In conclusion because enamel organ cells can interact with mesenchymal cells directly, and c-Met is expressed in the stages at which mesenchymal induction is guided by the dental epithelium, it is conceivable that c-Met is related to tooth germ morphogenesis and cell differentiation.
2009
tooth; human fetus; c-Met
File in questo prodotto:
File Dimensione Formato  
Ital J Anat Embryol_ 2009.pdf

solo gestori archivio

Tipologia: Versione Editoriale (PDF)
Licenza: Non specificato
Dimensione 3.57 MB
Formato Adobe PDF
3.57 MB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/6994
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact