Hydrogels for the buccal application of the anesthetic drug lidocaine hydrochloride (LDC) were preparedusing chitosan glutamate (CHG), a soluble salt of chitosan, or a binary mixture of CHG and glycerin, at differentweight ratios. The in vitro drug release was studied at the pH value of saliva to assess the effect of thedifferent formulations on drug delivery. The anesthetic activity of mucoadhesive LDC-CHG hydrogels wasassessed in vivo after application on the buccal mucosa, compared to commercial semisolid formulationscontaining the same drug. LDC-loaded hydrogels can be proposed for the symptom relief of aphthosis orother painful mouth diseases.
Chitosan glutamate hydrogels with local anesthetic activity for buccal application
PIGNATELLO, Rosario;PUGLISI, Giovanni
2009-01-01
Abstract
Hydrogels for the buccal application of the anesthetic drug lidocaine hydrochloride (LDC) were preparedusing chitosan glutamate (CHG), a soluble salt of chitosan, or a binary mixture of CHG and glycerin, at differentweight ratios. The in vitro drug release was studied at the pH value of saliva to assess the effect of thedifferent formulations on drug delivery. The anesthetic activity of mucoadhesive LDC-CHG hydrogels wasassessed in vivo after application on the buccal mucosa, compared to commercial semisolid formulationscontaining the same drug. LDC-loaded hydrogels can be proposed for the symptom relief of aphthosis orother painful mouth diseases.| File | Dimensione | Formato | |
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