Colorectal cancer: Prognostic and predictive response therapy factors.

Abstract: Colorectal cancer (CRC) is the third most common cancer worldwide. Its prognosis is closely related to the stage of the disease at the time of diagnosis. This is a review on the role of pathological classical factors, serum/clinical biomarkers and characteristics with prognostic and predictive response therapy value in the management of CRC- Clinical follow up in CRC is of paramount importance in the correct approach to this disease. Moreover, molecular studies have recently widened the opportunity for testing new possible markers, but actually, only few markers can be recommended for practical use in clinic. In the next future the hope will be to have a complete panel of clinical biomarkers to use in every setting of CRC disease, and at the same time to receive information about prognostic significance by their expression and to be oriented in the choice of the adequate treatment