The presence of copper(II) in the micromolar range modulates the photodegradation rate ofthe fluoroquinolone Rufloxacin (RFX), both under air and in nitrogen saturated aqueous solution. Thephotodegradation rate of RFX under aerobic conditions decreases in the presence of metal ions, and nochange in the nature of the photoproducts is observed. In anaerobic media, RFX photodegradation rateincreases with increasing copper(II) concentration and the photoproducts distribution changes.Copper(II) inhibits formation of type II products of 2'-deoxyguanosine diagnostic of photosensitizationmediated by singlet oxygen. The overall results provide a clear example demonstrating how a biocompatibletrace element influences efficiently not only the bioavailability of a drug but also itsmolecular mechanism of photodegradation and photosensitization.
Effects of bio-compatible metal ions on rufloxacin photochemistry, photophysics and photosensitization: Copper(II)
DE GUIDI, Guido
2010-01-01
Abstract
The presence of copper(II) in the micromolar range modulates the photodegradation rate ofthe fluoroquinolone Rufloxacin (RFX), both under air and in nitrogen saturated aqueous solution. Thephotodegradation rate of RFX under aerobic conditions decreases in the presence of metal ions, and nochange in the nature of the photoproducts is observed. In anaerobic media, RFX photodegradation rateincreases with increasing copper(II) concentration and the photoproducts distribution changes.Copper(II) inhibits formation of type II products of 2'-deoxyguanosine diagnostic of photosensitizationmediated by singlet oxygen. The overall results provide a clear example demonstrating how a biocompatibletrace element influences efficiently not only the bioavailability of a drug but also itsmolecular mechanism of photodegradation and photosensitization.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
