Contact with many different biological membranes goes along the destiny of a drug after its systemicadministration. From the circulating macrophage cells to the vessel endothelium, to more complex absorptionbarriers, the interaction of a biomolecule with these membranes largely affects its rate and time of biodistributionin the body and at the target sites. Therefore, investigating the phenomena occurring on the cell membranes,as well as their different interaction with drugs in the physiological or pathological conditions, is important toexploit the molecular basis of many diseases and to identify new potential therapeutic strategies. Of course,the complexity of the structure and functions of biological and cell membranes, has pushed researchers towardthe proposition and validation of simpler two- and three-dimensional membrane models, whose utility anddrawbacks will be discussed. This review also describes the analytical methods used to look at the interactionsamong bioactive compounds with biological membrane models, with a particular accent on the calorimetrictechniques. These studies can be considered as a powerful tool for medicinal chemistry and pharmaceuticaltechnology, in the steps of designing new drugs and optimizing the activity and safety profile of compoundsalready used in the therapy.
Biomembrane models and drug-biomembrane interaction studies: Involvement in drug design and development
PIGNATELLO, Rosario;MUSUMECI, TERESA;CARBONE, CLAUDIA;PUGLISI, Giovanni
2011-01-01
Abstract
Contact with many different biological membranes goes along the destiny of a drug after its systemicadministration. From the circulating macrophage cells to the vessel endothelium, to more complex absorptionbarriers, the interaction of a biomolecule with these membranes largely affects its rate and time of biodistributionin the body and at the target sites. Therefore, investigating the phenomena occurring on the cell membranes,as well as their different interaction with drugs in the physiological or pathological conditions, is important toexploit the molecular basis of many diseases and to identify new potential therapeutic strategies. Of course,the complexity of the structure and functions of biological and cell membranes, has pushed researchers towardthe proposition and validation of simpler two- and three-dimensional membrane models, whose utility anddrawbacks will be discussed. This review also describes the analytical methods used to look at the interactionsamong bioactive compounds with biological membrane models, with a particular accent on the calorimetrictechniques. These studies can be considered as a powerful tool for medicinal chemistry and pharmaceuticaltechnology, in the steps of designing new drugs and optimizing the activity and safety profile of compoundsalready used in the therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
