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<dc:title>Struttura e funzione arteriosa nelle malattie infiammatorie croniche intestinali</dc:title>
<dc:creator>RASTELLI, STEFANIA</dc:creator>
<dc:contributor>Rastelli, Stefania</dc:contributor>
<dc:contributor>CASTELLINO, Pietro</dc:contributor>
<dc:contributor>VICARI, Enzo Saretto</dc:contributor>
<dc:subject>Arterial stiffness, pulse wave velocity, inflammation, anti TNF-alpha, Crohn's disease, ulcerative colitis, inflammatory bowel disease</dc:subject>
<dc:description>Le malattie infiammatorie croniche intestinali (IBD) sono associate ad un aumentato rischio cardiovascolare non completamente spiegabile con la prevalenza dei fattori di rischio cardiovascolare tradizionali. L'infiammazione e l'aumento della rigidità arteriosa ad essa correlata potrebbero avere un ruolo importante nella valutazione del rischio cardiovascolare di questi soggetti. In questa tesi ho studiato la correlazione tra infiammazione e rigidità arteriosa nelle IBD. Per la prima volta ho riportato che i soggetti con IBD hanno un'aumentata rigidità arteriosa che può essere normalizzata dall'uso di farmaci anti TNF-alfa.</dc:description>
<dc:description>Background. Inflammatory bowel diseases (IBD) are associated with an increased cardiovascular risk that is not fully explained by traditional cardiovascular risk factors but may be due to inflammation and mediated by an increased arterial stiffness. In this work I have investigated the relationship between inflammation and arterial stiffening. For the first time I have reported aortic stiffening in IBD, which can be reduced by anti TNF-alpha therapy.</dc:description>
<dc:date>2014-12-09</dc:date>
<dc:type>info:eu-repo/semantics/doctoralThesis</dc:type>
<dc:identifier>https://hdl.handle.net/20.500.11769/586591</dc:identifier>
<dc:language>ita</dc:language>
<dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
<dc:publisher>Università degli studi di Catania</dc:publisher>
<dc:publisher>place:Catania</dc:publisher>
<dc:rights>license:PUBBLICO - Pubblico con Copyright</dc:rights>
<dc:rights>license uri:iris.PUB02</dc:rights>
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