<?xml version="1.0" encoding="UTF-8"?><?xml-stylesheet type="text/xsl" href="static/CINECAstyle.xsl"?><OAI-PMH xmlns="http://www.openarchives.org/OAI/2.0/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/ http://www.openarchives.org/OAI/2.0/OAI-PMH.xsd"><responseDate>2026-09-25T01:00:18Z</responseDate><request verb="GetRecord" identifier="oai:www.iris.unict.it:20.500.11769/587980" metadataPrefix="oai_dc">https://www.iris.unict.it/oai/request</request><GetRecord><record><header><identifier>oai:www.iris.unict.it:20.500.11769/587980</identifier><datestamp>2024-01-23T00:46:41Z</datestamp><setSpec>com_20.500.11769_434851</setSpec><setSpec>com_123456789_40</setSpec><setSpec>col_20.500.11769_434852</setSpec></header><metadata><oai_dc:dc xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:doc="http://www.lyncode.com/xoai" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:dc="http://purl.org/dc/elements/1.1/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
<dc:title>IL SURRENE NELLA CIRROSI EPATICA: LA SINDROME EPATO-SURRENALICA</dc:title>
<dc:creator>FEDE, GIUSEPPE</dc:creator>
<dc:contributor>Fede, Giuseppe</dc:contributor>
<dc:contributor>PURRELLO, Francesco</dc:contributor>
<dc:contributor>FRITTITTA, Lucia</dc:contributor>
<dc:subject>Adrenal, insufficiency, cirrhosis, cortisol</dc:subject>
<dc:description>L'Insufficienza surrenalica (IS), definita da deficit di sintesi o di azione dei glucocorticoidi, dovuto ad un danno strutturale del surrene (IS primitiva) oppure ad un alterazione dell'asse ipotalamo-ipofisario (IS secondaria), è stata riscontrata con frequenza sempre maggiore in pazienti con epatopatie acute e croniche, ed alcuni autori hanno proposto il termine "sindrome epato-surrene". La prevalenza di IS nei pazienti con malattia epatica varia a seconda della popolazione studiata: pazienti con eventi acuti (33% -92%), cirrosi stabile (31% -60%), o cirrosi scompensata, come il sanguinamento da varici esofagee (30% - 48%) e ascite (26% -64%). Tuttavia non c'è consenso corrente sui criteri diagnostici per definire l'IS nei pazienti con malattia epatica, e non è ancora chiarita la sua rilevanza nella prognosi dei pazienti con cirrosi stabile.</dc:description>
<dc:description>Adrenal Insufficiency (AI), defined as deficient production or action of glucocorticoids resulting from either a structural damage of adrenal glands (primary adrenal insufficiency) or an impairment of the hypothalamic-pituitary axis (secondary adrenal disease), is being reported with increasing frequency in patients with liver disease, and some authors proposed the term  hepato-adrenal syndrome . The prevalence of AI in patients with liver disease varies widely according to the study population: critically ill patients (33%-92%), stable cirrhosis (31%-60%), or decompensated cirrhosis, such as variceal bleeding (30%-48%) and ascites (26%-64%). However there is no current consensus about diagnostic criteria to define AI in patients with liver disease, and its prognostic relevance in stable cirrhosis is still unclear.</dc:description>
<dc:date>2013-12-09</dc:date>
<dc:type>info:eu-repo/semantics/doctoralThesis</dc:type>
<dc:identifier>https://hdl.handle.net/20.500.11769/587980</dc:identifier>
<dc:language>ita</dc:language>
<dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
<dc:publisher>Università degli studi di Catania</dc:publisher>
<dc:publisher>place:Catania</dc:publisher>
<dc:rights>license:PUBBLICO - Pubblico con Copyright</dc:rights>
<dc:rights>license uri:iris.PUB02</dc:rights>
</oai_dc:dc></metadata></record></GetRecord></OAI-PMH>