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<dc:title>ESPRESSIONE DELL'IL-17A NELLA DINAMICA PATOGENETICA DELLA POLIPOSI NASALE</dc:title>
<dc:creator>PREVITERA, AGATA MARIA</dc:creator>
<dc:contributor>Previtera, AGATA MARIA</dc:contributor>
<dc:contributor>SERRA, Agostino</dc:contributor>
<dc:contributor>SERRA, Agostino</dc:contributor>
<dc:subject>nasal polyposis, Interleukin-17A,eosinophil</dc:subject>
<dc:description>LA POLIPOSI NASALE E' UNA PATOLOGIA DI FREQUENTE RISCONTRO NELLA PRATICA OTORINOLARINGOIATRICA ED E' DEFINIBILE COME UN PROCESSO FLOGISTICO CRONICO DELLA CAVITA' NASALE E SINUSALE. ALLA LUCE DELLE ODIERNE CONOSCENZE IL TRATTAMENTO CON FARMACI ANTIBIOTICI, STEROIDI O TERAPIE CHIRURGICHE NON SEMPRE SONO SODDISFACENTI ED IL TASSO DI RECIDIVA RIMANE ELEVATO. LA POLIPOSI NASALE HA UN'IMPORTANTE RILEVANZA SOCIALE SIA PER LA SUA ELEVATA INCIDENZA (2-5% DELLA POPOLAZINE MONDIALE) SIA PER LE SUE RIPERCUSSIONI IN TERMINI DI SPESA SANITARIA. I MECCANISMI PATOGENETICI ALLA BASE DI TALE PATOLOGIA RIMANGONO ANCORA POCO CHIARI NONOSTANTE SIANO STATI EFFETTUATI NUMEROSI STUDI; SEMBRA CHE L'IL-17A SVOLGA UN RUOLO IMPORTANTE NELLA PATOGENESI DELLA POLIPOSI NASALE.</dc:description>
<dc:description>Nasal polyposis (NP), commonly encountered in&#xd;
clinical otorhinolaryngology, is a chronic&#xd;
inflammatory disease of the nasal cavity and sinus.&#xd;
At present the treatment outcomes of antibiotics,&#xd;
steroids, and surgery for NP are unsatisfactory and&#xd;
the recurrence rate remains high. NP has become a&#xd;
more and more important social issue because of its&#xd;
high incidence (2 5% worldwide) and the&#xd;
considerable economic burden associated with the&#xd;
disease.The pathogenesis of NP&#xd;
has been studied widely, but it is not clearly&#xd;
understood, IL-17A&#xd;
may play an important role in the pathology of&#xd;
NP and atopy may contribute to NP by&#xd;
stimulating the production of IL-17A.</dc:description>
<dc:date>2011-12-07</dc:date>
<dc:type>info:eu-repo/semantics/doctoralThesis</dc:type>
<dc:identifier>https://hdl.handle.net/20.500.11769/593509</dc:identifier>
<dc:language>ita</dc:language>
<dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
<dc:publisher>Università degli studi di Catania</dc:publisher>
<dc:publisher>place:Catania</dc:publisher>
<dc:rights>license:PUBBLICO - Pubblico con Copyright</dc:rights>
<dc:rights>license uri:iris.PUB02</dc:rights>
</oai_dc:dc></metadata></record></GetRecord></OAI-PMH>