BACKGROUND: Effective management of chronic hepatitis B infection is still very challenging, despite decades of clinical research. Telbivudine is one of the most frequently used antiviral drug at the current stage, but its long-term effectiveness, particularly at off-treatment, is still unclear. OBJECTIVES: To assess on-treatment HBsAg kinetics in patients treated with telbivudine for 2 years, and predicting sustained virologic response (SR) at 2 years off-treatment. STUDY DESIGN: Serum HBV DNA/HBsAg levels were assessed from 12 HBeAg negative patients treated with telbivudine 600 mg/day for 104 weeks, at baseline, weeks 24, 52 and 104, as well as during off-treatment follow-up. Serum levels HBsAg was quantified using the Abbott ARCHITET assay and HBV-DNA using the Abbott assay. Aggiungere metodica dosaggio HBV-DNA RESULTS: HBsAg levels <2 log(10)IU/ml at treatment week 104 were highly predictive of SR (i.e., HBV DNA <300 copies/ml or undetectable, ALT normalization) at 2 years off-treatment (positive predictive value [PPV], 93%; negative predictive value [NPV], 100%). HBsAg levels consistently declined from baseline only in patients achieving SR during 2 years off-treatment. At weeks 24 and 52, HBsAg decline rate was a better predictor of off-treatment response than HBV DNA decline rate. HBsAg decline rates of >0.8 and >1 log(10)IU/ml at treatment weeks 24 and 52 were predictive of SR (PPV, 75%; NPV, 86% at week 24; PPV, 75%; NPV, 86% at week 52). CONCLUSIONS: Serum HBsAg levels <2 log(10)IU/ml at treatment week 104 are highly predictive of SR to telbivudine at 2 years off-treatment. HBsAg decline rate at on-treatment weeks 24 and 52 from baseline were also more predictive of SR than HBV DNA decline rate.
|Titolo:||On-treatment serum HBsAg level is predictive of sustained off-treatment virologic response to telbivudine in HBeAg-negative chronic hepatitis B patients|
|Data di pubblicazione:||2010|
|Citazione:||On-treatment serum HBsAg level is predictive of sustained off-treatment virologic response to telbivudine in HBeAg-negative chronic hepatitis B patients / BERTINO G; ARDIRI A; CALVAGNO GS; BOEMI PM; SANTONOCITO MM; CAMPAGNA D; NERI S. - In: INTERNAL AND EMERGENCY MEDICINE. - ISSN 1828-0447. - 5:supplement 2(2010), pp. S154-S154. ((Intervento presentato al convegno 111th National Congress of the Italian Society of Internal Medicine tenutosi a Roma nel 16-19 Ottobre 2010.|
|Appare nelle tipologie:||4.3 Poster|