The properties as a drug carrier of the biodegradable polymer, α,β-poly(N-hydroxyethyl)-dl-aspartamide (PHEA) were investigated. Thus, naproxen- and 4-biphenylacetic acid-PHEA adducts were prepared and characterized; drug content was evaluated by both UV and elemental analysis and hydrolysis of the adducts. In vivo analgesic and anti-inflammatory tests indicated that the adducts retain an activity comparable to that of the free drugs.
|Titolo:||Polymeric prodrugs: α,β-poly(N-hydroxyethyl)-dl-aspartamide as a macromolecular carrier for some non-steroidal anti-inflammatory agents|
|Data di pubblicazione:||1989|
|Appare nelle tipologie:||1.1 Articolo in rivista|