Background and aim:Irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD) are frequently diagnosed in clinical practice. The clinical encounter of symptoms associated with these two disorders is often concomitant. The aim of the study is to assess the correlation between IBS and GERD, IBS and Erosive Reflux Disease (ERD) and IBS and Non-erosive Reflux Disease (NERD). Material and methods:We evaluated 710 pts (210 M-30% and 500 F-70%; mean age: 48 yrs-range 15–88 yrs) referring to our ambulatory of gastrointestinal disease from November 2010 to October 2012. Five hundred and forty-two pts (n=542/710 – 64%) had GERD and/or IBS symptoms (according to ROMA III criteria). GERD pts with or without IBS (n=275/542), were diagnosed with ERD (n=99/275 – 36%) or NERD (n=176/275 – 64%) by endoscopic examination. Statistical analysis was performed with using chi-square test and odds ratio. Results:The comparative analysis between IBS pts (n=321/542) and GERD pts, and IBS pts and NERD pts evidenced a modest positive association (GERD: OR=1.6, 95% CI: 1.18–2.17, p<0.025; NERD: OR=1.6, 95% CI: 1.13–2.25, p<0.025), whereas ERD had a slight relationship with IBS (ERD: OR=1.22, 95% CI: 0.80–1.87, p=ns). Conclusions:These results show an overlapping of GERD in a 45% of IBS pts (n=144/321). A common functional starting problem could explain this association, as well as the improvement of IBS-like symptoms in patients with reflux disease receiving anti-reflux treatment, as confirmed by studies. Further studies looking at all the putative variables involved in symptom perception and response to therapy are needed in these subgroups of patients.
|Titolo:||OVERLAPPING OF GASTROESOPHAGEAL REFLUX DISEASE AND IRRITABLE BOWEL SYNDROME.|
|Data di pubblicazione:||2013|
|Appare nelle tipologie:||4.2 Abstract in Atti di convegno|