Background and aim:Irritable Bowel Syndrome (IBS) and Gastroesophageal Reflux Disease (GERD) are very common disorders in the general population. Symptoms associated with these two disorders are often concomitant in clinical practice. The aim of the study is to assess the correlation between GERD and IBS subgroups. Material and methods:Seven hundred and ten pts (210 M-30% and 500 F-70%; mean age: 48 yrs-range 15–88 yrs) referring to our ambulatory of gastrointestinal disease were evaluated from November 2010 to October 2012. Five hundred and forty-two pts (n=542/710 – 64%) had GERD and/or IBS symptoms (according to ROMA III criteria). In particular, GERD-only pts were 131, IBS-only pts were 177 and GERD-IBS pts were 144. We divided pts in three subgroups for IBS-only (IBS-constipation-IBS-C = 46/177, IBS-diarrhea-IBS-D = 65/177, IBS-CD=66/177) and for IBS-GERD (IBS-C = 47/144, IBS-D = 47/144, IBS-CD = 50/144). Statistical analysis was performed with using chi-square test and odds ratio (OR). Results:The comparative analysis between GERD pts and IBS subgroups pts evidenced a moderate positive association only for IBS-C subgroup (IBS-C: OR=1.74, 95% CI: 1.12–2.70, p<0.025), whereas IBS-D and IBS-CD had not a relationship with GERD (IBS-D: OR=1.17, 95% CI: 0.78–1.77, p=ns; IBS-CD: OR=1.24, 95% CI: 0.83–1.86, p=ns). Conclusions:These results show a positive relationship between GERD and IBS-C. This relationship could be explained admitting the existence of a common functional starting problem or, as confirmed by studies, an improvement of IBS-like symptoms in patients with reflux disease receiving anti-reflux treatment. Due to our limited cases, further studies are needed to clarify the pathophysiological basis that could correlate the two motility disorders and for a rational therapeutic approach.
|Titolo:||IRRITABLE BOWEL SYNDROME: SUBGROUPS AND RELATIONSHIP WITH GASTROESOPHAGEAL REFLUX DISEASE.|
|Data di pubblicazione:||2013|
|Appare nelle tipologie:||4.2 Abstract in Atti di convegno|