Considering the role played by metalloproteases in neuroinflammation and in the development of neuropathic pain, several structural variations of benzomorphan derivatives, possessing relevant binding affinity and selectivity for MOR receptors, vs KOR and DOR, as well as good selectivity and inhibition capability for MMP-9 enzyme vs MMP-2 and MMP-3 were synthesized and evaluated.
In-silico design and biological investigations of Diabetic Neuropathy modulators: could MOR become a focal mediator for this pathology?
Simone Ronsisvalle
;Livia Basile;Barbara Tomasello;Salvatore Guccione;Matteo Pappalardo
2020-01-01
Abstract
Considering the role played by metalloproteases in neuroinflammation and in the development of neuropathic pain, several structural variations of benzomorphan derivatives, possessing relevant binding affinity and selectivity for MOR receptors, vs KOR and DOR, as well as good selectivity and inhibition capability for MMP-9 enzyme vs MMP-2 and MMP-3 were synthesized and evaluated.File in questo prodotto:
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