In this paper review we describe benefits and disadvan- tages of the established methods of cartilage regenera- tion that seem to have a better long-term effectiveness. We illustrated the anatomical aspect of the knee joint cartilage, the current state of cartilage tissue engineer- ing, through mesenchymal stem cells and biomaterials, and in conclusion we provide a short overview on the rehabilitation after articular cartilage repair procedures. Adult articular cartilage has low capacity to repair itself, and thus even minor injuries may lead to progressive damage and osteoarthritic joint degeneration, result- ing in significant pain and disability. Numerous efforts have been made to develop tissue-engineered grafts or patches to repair focal chondral and osteochondral defects, and to date several researchers aim to imple- ment clinical application of cell-based therapies for cartilage repair. A literature review was conducted on PubMed, Scopus and Google Scholar using appropriate keywords, examining the current literature on the well- known tissue engineering methods for the treatment of knee osteoarthritis.
|Titolo:||New perspectives for articular cartilage repair treatment through tissue engineering: A contemporary review|
|Data di pubblicazione:||2014|
|Appare nelle tipologie:||1.1 Articolo in rivista|