The antidepressant potential of repetitive transcranial magnetic stimulation (rTMS) is widely recognized [1], whereas the impact on the neurotrophins involved in major depression (MD) and vascular depression (VD) has not been fully investigated yet [2-3]. We evaluated the effect of rTMS on mood, cognition, neurotrophic factors, motor evoked potentials (MEPs) to TMS, and cerebral blood flow (CBF) to transcranial doppler (TCD) in a pilot series of MD and VD patients. Improvement in mood and cognitive scores were observed after rTMS and persisted for at least 3 months. MEP amplitude increased and cortical silent period shortened. A bilateral increase in CBF was observed. BDNF and VEGF showed the largest variation in MD patients, whereas ANG and IGF-1 in those with VD; NGF did not change significantly. we confirmed the positive effects on mood and cognition of HF-rTMS, supported by multimodal evidence, thus suggesting a pleiotropic effect of rTMS. However, the suitability of each marker as an index of outcome measure or neuromodulatory factor requires further understanding.

PC012 / #460 Multimodal Effects Of Repetitive Transcranial Magnetic Stimulation On Patients With Major Depression And Vascular Depression: A Pilot Study

Lanza, Giuseppe;Fisicaro, Francesco;Nicoletti, Vincenzo;Saitta, Giulia;Meo, Valeria;Pennisi, Manuela;Bella, Rita;Aguglia, Eugenio
2022-01-01

Abstract

The antidepressant potential of repetitive transcranial magnetic stimulation (rTMS) is widely recognized [1], whereas the impact on the neurotrophins involved in major depression (MD) and vascular depression (VD) has not been fully investigated yet [2-3]. We evaluated the effect of rTMS on mood, cognition, neurotrophic factors, motor evoked potentials (MEPs) to TMS, and cerebral blood flow (CBF) to transcranial doppler (TCD) in a pilot series of MD and VD patients. Improvement in mood and cognitive scores were observed after rTMS and persisted for at least 3 months. MEP amplitude increased and cortical silent period shortened. A bilateral increase in CBF was observed. BDNF and VEGF showed the largest variation in MD patients, whereas ANG and IGF-1 in those with VD; NGF did not change significantly. we confirmed the positive effects on mood and cognition of HF-rTMS, supported by multimodal evidence, thus suggesting a pleiotropic effect of rTMS. However, the suitability of each marker as an index of outcome measure or neuromodulatory factor requires further understanding.
major depression, vascular depression, transcranial doppler, rTMS, neurotrophins
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/544701
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