Synthesis and biological evaluation of pirrolidine, oxazolidin-2-imine and mercaptoketones derivates as HCV, HIV and HDAC inhibitors

The main objective of this thesis was the synthesis of modified azanucleosides potential ihibitors of non-structural proteins of HCV virus ((NS) NS3/4A, NS4B, NS5A and NS5B). Moreover the research project included the synthesis of pyrimidine-1,3-oxazolidin-2-arylimino hybrids as HIV ihibitors and the synthesis of mercaptoketone deriatives as antitumor agents potential HDAC's inhibitor.