The neurovascular coupling is the process by which the neurovascular unit modulates the complex relationship between neuronal activity, hemodynamic factors and intracellular signaling. Recent studies identify the possible association between alterations in cerebral hemodynamic and the impairment of cognitive performance, partly due to an impairment of physiological signaling between the elements of the neurovascular unit. Objective of the study is to investigate the possible relationship between cognitive disturbances and alterations in cerebrovascular reactivity in patients with Parkinson's disease (PD). We evaluated a population of 34 patients (22 males and 12 females) with PD according to UK Brain Bank Criteria and subjected to clinical evaluation, neuropsychological and motor, autonomic function evaluation by SCOPA-AUT, assessment of lesion load of the white matter with Magnetic Resonance Cerebral applying visual semiquantitative scale CHS and assessment Ultrasound TSA and TCD, including evaluation of cerebrovascular reactivity by Breath Holding Index (BHI). The population was divided into two groups one with and one without Mild Cognitive Impairment (MCI) according to Diagnostic Criteria for PD-MC from Litvan I 2012. From the results obtained hemodynamic parameters assessed by TCD showed no significant differences at baseline of VMF MCA and PCA. After hypercapnic stimulus there was a statistically significant difference in cerebrovascular reactivity resulting in reduced group PD-MCI.
Il neurovascula coupling indica il processo mediante il quale l unità neuro vascolare modula la complessa relazione tra attività neuronale, fattori emodinamici e segnali intracellulari. Recenti studi individuano la possibile associazione tra alterazioni dell emodinamica cerebrale e il decadimento della performance cognitiva,in parte riconducibile ad una compromissione del fisiologico signaling tra gli elementi dell unità neuro vascolare. Obiettivo dello studio è quello di indagare la possibile relazione tra disturbi cognitivi ed alterazioni della reattività cerebrovascolare in pazienti affetti da Malattia di Parkinson (MdP). È stata valutata una popolazione di 34 pazienti (22 maschi e 12 femmine) affetti da MdP in accordo con UK brain bank Criteria e sottoposta a valutazione clinica,motoria e neuropsicologica,valutazione della funzionalità autonomica mediante SCOPA-AUT,valutazione del carico lesionale della sostanza bianca mediante Risonanza Magnetica Cerebrale applicando la scala visiva semiquantitativa CHS e dettagliata valutazione Ultrasonografica TSA e TCD ,inclusa valutazione della reattività cerebrovascolare mediante Breath Holding Index (BHI). La popolazione è stata divisa in due gruppi in base alla presenza di Mild cognitive Impairment (MCI) in accordo con Diagnostic Criteria for PD-MC da Litvan I 2012. Dai risultati ottenuti i parametri emodinamici valutati mediante TCD non hanno evidenziato differenze significative al baseline di VMF MCA e PCA. Dopo stimolo ipercapnico si è osservata una differenza statisticamente significativa della reattività cerebrovascolare risultando ridotta nel gruppo PD-MCI.
Parkinson's disease and degenerative parkinsonism: relationship between clinical and neurobiological aspects / Scatozza, Rossella. - (2014 Dec 05).
Parkinson's disease and degenerative parkinsonism: relationship between clinical and neurobiological aspects
SCATOZZA, ROSSELLA
2014-12-05
Abstract
The neurovascular coupling is the process by which the neurovascular unit modulates the complex relationship between neuronal activity, hemodynamic factors and intracellular signaling. Recent studies identify the possible association between alterations in cerebral hemodynamic and the impairment of cognitive performance, partly due to an impairment of physiological signaling between the elements of the neurovascular unit. Objective of the study is to investigate the possible relationship between cognitive disturbances and alterations in cerebrovascular reactivity in patients with Parkinson's disease (PD). We evaluated a population of 34 patients (22 males and 12 females) with PD according to UK Brain Bank Criteria and subjected to clinical evaluation, neuropsychological and motor, autonomic function evaluation by SCOPA-AUT, assessment of lesion load of the white matter with Magnetic Resonance Cerebral applying visual semiquantitative scale CHS and assessment Ultrasound TSA and TCD, including evaluation of cerebrovascular reactivity by Breath Holding Index (BHI). The population was divided into two groups one with and one without Mild Cognitive Impairment (MCI) according to Diagnostic Criteria for PD-MC from Litvan I 2012. From the results obtained hemodynamic parameters assessed by TCD showed no significant differences at baseline of VMF MCA and PCA. After hypercapnic stimulus there was a statistically significant difference in cerebrovascular reactivity resulting in reduced group PD-MCI.File | Dimensione | Formato | |
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