In recent years, Insulin-Degrading Enzyme (IDE) has drawn attention because of its capability to degrade β-amyloid peptides as well as insulin and it is currently studied as a pharmacological target for Alzheimer's disease. Our group has already reported that IDE activity can be conveniently screened by mass spectrometric methods. Particularly, in this work the unique potentiality of mass spectrometry to study the cryptic peptides generated by the action of IDE on some of its substrates will be described.
The application of mass spectrometry for the analysis of the cryptic peptides produced by the action of IDE on some of its substrates
GRASSO, GIUSEPPE
2015-01-01
Abstract
In recent years, Insulin-Degrading Enzyme (IDE) has drawn attention because of its capability to degrade β-amyloid peptides as well as insulin and it is currently studied as a pharmacological target for Alzheimer's disease. Our group has already reported that IDE activity can be conveniently screened by mass spectrometric methods. Particularly, in this work the unique potentiality of mass spectrometry to study the cryptic peptides generated by the action of IDE on some of its substrates will be described.File in questo prodotto:
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