The purpose was to investigate the percutaneous absorption of naproxen (NPX), used as model anti-inflammatory drug, included in liposomes composed of different lipids, namely stratum corneum lipids (SCL) and phosphatidylcholine/cholesterol (PC/CHOL).The results of our work outlined how lipid composition of liposomal vesicles could modify the permeation profile of a well-known NSAID, such as NPX. In particular, SCL liposomes demonstrated drug penetration reduction due to the formation of a drug depot in the stratum corneum. On the other hand PC/CHOL liposomes promoted drug permeation in vivo, probably modifying the skin permeability properties. The obtained results may be of value in a rational design and development of dermal formulations
Liposomal formulations for percutaneous absorption of naproxen: a comparative study
PUGLIA, CARMELO;
2011-01-01
Abstract
The purpose was to investigate the percutaneous absorption of naproxen (NPX), used as model anti-inflammatory drug, included in liposomes composed of different lipids, namely stratum corneum lipids (SCL) and phosphatidylcholine/cholesterol (PC/CHOL).The results of our work outlined how lipid composition of liposomal vesicles could modify the permeation profile of a well-known NSAID, such as NPX. In particular, SCL liposomes demonstrated drug penetration reduction due to the formation of a drug depot in the stratum corneum. On the other hand PC/CHOL liposomes promoted drug permeation in vivo, probably modifying the skin permeability properties. The obtained results may be of value in a rational design and development of dermal formulationsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
