COSTANZO, GIULIANA
COSTANZO, GIULIANA
SCIENZE DEL FARMACO E DELLA SALUTE (DSFS) (Department of Drug and Health Sciences)
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain
2022-01-01 Spoto, Salvatore; Pasquinucci, Lorella Giuseppina; Turnaturi, Rita; Costanzo, Giuliana; Chiechio, Santina; Vicario, Nunzio; Parenti, Rosalba; Marrazzo, Agostino; Amata, Emanuele; Parenti, Carmela
Design, Synthesis and biological evaluation of hybrid MOR agonist/ HDACi molecules as potential therapeutic agents for chronic pain treatment
file da validare2021-01-01 Costanzo, Giuliana; Turnaturi, Rita; Barbaraci, Carla; Marrazzo, Agostino; Pasquinucci, Lorella Giuseppina
Design, synthesis and biological evaluation of MOR agonist/HDACi hybrid compounds: a new potential therapeutic strategy for persistent pain management
2021-01-01 Costanzo, Giuliana; Turnaturi, Rita; Marrazzo, Agostino; Pasquinucci, Lorella
Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management
2022-01-01 Costanzo, Giuliana; Mahmoud, Al-Khrasani; Turnaturi, Rita; Amata, Emanuele; Marrazzo, Agostino; Parenti, Carmela; Pasquinucci, Lorella Giuseppina
Designing drugs optimized for both blood-brain barrier permeation and intra-cerebral partition
file da validare2023-01-01 Dichiara, Maria; Cosentino, Giuseppe; Giordano, Giorgia; Pasquinucci, Lorella; Marrazzo, Agostino; Costanzo, Giuliana; Amata, Emanuele
Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity
2023-01-01 Dichiara, Maria; Ambrosio Francesca, Alessandra; Lee Sang, Min; Ruiz-Cantero M., Carmen; Lombino, Jessica; Coricello, Adriana; Costa, Giosuè; Shah, Dhara; Costanzo, Giuliana; Pasquinucci, Lorella Giuseppina; Son Kyung, No; Cosentino, Giuseppe; González-Cano, Rafael; Marrazzo, Agostino; Aakalu Vinay, Kumar; Cobos Enrique, J.; Alcaro, Stefano; Amata, Emanuele
From Plant to Chemistry: Sources of Active Opioid Antinociceptive Principles for Medicinal Chemistry and Drug Design
file da validare2023-01-01 Turnaturi, Rita; Piana, Silvia; Spoto, Salvatore; Costanzo, Giuliana; Reina, Lorena; Pasquinucci, Lorella; Parenti, Carmela
Hybrid MOR agonist/HDACi molecules as potential antinociceptive multi-target drugs: design, synthesis, and biological evaluation
file da validare2022-01-01 Costanzo, Giuliana; Turnaturi, Rita; Marrazzo, Agostino; Amata, Emanuele; Parenti, Carmela; Pasquinucci, Lorella
Hybrid MOR agonist/HDACi molecules as potential new drugs for persistant pain management: design, synthesis and biological evaluation
file da validare2021-01-01 Costanzo, Giuliana; Turnaturi, Rita; Marrazzo, Agostino; Pasquinucci, Lorella Giuseppina
MOR/DOR Dual-Target Approach: 2S-LP2 Effects in Inflammatory and Neuropathic Pain
2022-01-01 Spoto, Salvatore; Pasquinucci, Lorella; Turnaturi, Rita; Marrazzo, Agostino; Amata, Emanuele; Costanzo, Giuliana; Chiechio, Santina; Parenti, Carmela
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands
2023-01-01 Costanzo, Giuliana; Turnaturi, Rita; Parenti, Carmela; Spoto, Salvatore; Piana, Silvia; Dichiara, Maria; Zagni, Chiara; Galambos, Anna Rita; Essmat, Nariman; Marrazzo, Agostino; Amata, Emanuele; Al-Khrasani, Mahmoud; Pasquinucci, Lorella
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics for Pain Treatment
2023-01-01 Costanzo, Giuliana; Vicario, Nunzio; Turnaturi, Rita; Marrazzo, Agostino; Amata, Emanuele; Parenti, Carmela; Pasquinucci, Lorella
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain
2022-01-01 Turnaturi, Rita; Chiechio, Santina; Pasquinucci, Lorella; Spoto, Salvatore; Costanzo, Giuliana; Dichiara, Maria; Piana, Silvia; Grasso, Margherita; Amata, Emanuele; Marrazzo, Agostino; Parenti, Carmela
NOVEL N-NORMETAZOCINE DERIVATIVES WITH SIGMA-1 RECEPTOR ANTAGONIST PROFILE AS POTENTIAL ANALGESICS FOR INFLAMMATORY PAIN MANAGEMENT
file da validare2023-01-01 Costanzo, G.; Cosentino, G.; Patamia, V.; Turnaturi, R.; Parenti, C.; Rescifina, A.; Marrazzo, A.; Amata, E; Pasquinucci, L.
SYNTHESIS, COMPUTATIONAL INSIGHTS, AND EVALUATION OF NOVEL SIGMA RECEPTORS LIGANDS
2023-01-01 Dichiara, M.; Ambrosio, F. A.; Barbaraci, C.; Shah, D.; Gonzàles-Cano, R.; Ruiz-Cantero, C.; Coricello, A.; Costa, G.; Lee, S. M.; Son, K. N.; Lombino, J.; Costanzo, G.; Cosentino, G.; Giordano, G.; Pasquinucci, L.; Marrazzo, A.; Aakalu, V. K.; Cobos, E. J.; Alcaro, S.; Amata, E.
Synthesis, in vitro evaluation, and molecular modeling studies of LP2 analogs
2022-01-01 Costanzo, Giuliana; Patamia, Vincenzo; Amata, Emanuele; Rescifina, Antonio; Lorella Pasquinucci, And
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain | 1-gen-2022 | Spoto, Salvatore; Pasquinucci, Lorella Giuseppina; Turnaturi, Rita; Costanzo, Giuliana; Chiechio, Santina; Vicario, Nunzio; Parenti, Rosalba; Marrazzo, Agostino; Amata, Emanuele; Parenti, Carmela | |
| Design, Synthesis and biological evaluation of hybrid MOR agonist/ HDACi molecules as potential therapeutic agents for chronic pain treatment | 1-gen-2021 | Costanzo, Giuliana; Turnaturi, Rita; Barbaraci, Carla; Marrazzo, Agostino; Pasquinucci, Lorella Giuseppina | file da validare |
| Design, synthesis and biological evaluation of MOR agonist/HDACi hybrid compounds: a new potential therapeutic strategy for persistent pain management | 1-gen-2021 | Costanzo, Giuliana; Turnaturi, Rita; Marrazzo, Agostino; Pasquinucci, Lorella | |
| Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management | 1-gen-2022 | Costanzo, Giuliana; Mahmoud, Al-Khrasani; Turnaturi, Rita; Amata, Emanuele; Marrazzo, Agostino; Parenti, Carmela; Pasquinucci, Lorella Giuseppina | |
| Designing drugs optimized for both blood-brain barrier permeation and intra-cerebral partition | 1-gen-2023 | Dichiara, Maria; Cosentino, Giuseppe; Giordano, Giorgia; Pasquinucci, Lorella; Marrazzo, Agostino; Costanzo, Giuliana; Amata, Emanuele | file da validare |
| Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity | 1-gen-2023 | Dichiara, Maria; Ambrosio Francesca, Alessandra; Lee Sang, Min; Ruiz-Cantero M., Carmen; Lombino, Jessica; Coricello, Adriana; Costa, Giosuè; Shah, Dhara; Costanzo, Giuliana; Pasquinucci, Lorella Giuseppina; Son Kyung, No; Cosentino, Giuseppe; González-Cano, Rafael; Marrazzo, Agostino; Aakalu Vinay, Kumar; Cobos Enrique, J.; Alcaro, Stefano; Amata, Emanuele | |
| From Plant to Chemistry: Sources of Active Opioid Antinociceptive Principles for Medicinal Chemistry and Drug Design | 1-gen-2023 | Turnaturi, Rita; Piana, Silvia; Spoto, Salvatore; Costanzo, Giuliana; Reina, Lorena; Pasquinucci, Lorella; Parenti, Carmela | file da validare |
| Hybrid MOR agonist/HDACi molecules as potential antinociceptive multi-target drugs: design, synthesis, and biological evaluation | 1-gen-2022 | Costanzo, Giuliana; Turnaturi, Rita; Marrazzo, Agostino; Amata, Emanuele; Parenti, Carmela; Pasquinucci, Lorella | file da validare |
| Hybrid MOR agonist/HDACi molecules as potential new drugs for persistant pain management: design, synthesis and biological evaluation | 1-gen-2021 | Costanzo, Giuliana; Turnaturi, Rita; Marrazzo, Agostino; Pasquinucci, Lorella Giuseppina | file da validare |
| MOR/DOR Dual-Target Approach: 2S-LP2 Effects in Inflammatory and Neuropathic Pain | 1-gen-2022 | Spoto, Salvatore; Pasquinucci, Lorella; Turnaturi, Rita; Marrazzo, Agostino; Amata, Emanuele; Costanzo, Giuliana; Chiechio, Santina; Parenti, Carmela | |
| New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands | 1-gen-2023 | Costanzo, Giuliana; Turnaturi, Rita; Parenti, Carmela; Spoto, Salvatore; Piana, Silvia; Dichiara, Maria; Zagni, Chiara; Galambos, Anna Rita; Essmat, Nariman; Marrazzo, Agostino; Amata, Emanuele; Al-Khrasani, Mahmoud; Pasquinucci, Lorella | |
| Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics for Pain Treatment | 1-gen-2023 | Costanzo, Giuliana; Vicario, Nunzio; Turnaturi, Rita; Marrazzo, Agostino; Amata, Emanuele; Parenti, Carmela; Pasquinucci, Lorella | |
| Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain | 1-gen-2022 | Turnaturi, Rita; Chiechio, Santina; Pasquinucci, Lorella; Spoto, Salvatore; Costanzo, Giuliana; Dichiara, Maria; Piana, Silvia; Grasso, Margherita; Amata, Emanuele; Marrazzo, Agostino; Parenti, Carmela | |
| NOVEL N-NORMETAZOCINE DERIVATIVES WITH SIGMA-1 RECEPTOR ANTAGONIST PROFILE AS POTENTIAL ANALGESICS FOR INFLAMMATORY PAIN MANAGEMENT | 1-gen-2023 | Costanzo, G.; Cosentino, G.; Patamia, V.; Turnaturi, R.; Parenti, C.; Rescifina, A.; Marrazzo, A.; Amata, E; Pasquinucci, L. | file da validare |
| SYNTHESIS, COMPUTATIONAL INSIGHTS, AND EVALUATION OF NOVEL SIGMA RECEPTORS LIGANDS | 1-gen-2023 | Dichiara, M.; Ambrosio, F. A.; Barbaraci, C.; Shah, D.; Gonzàles-Cano, R.; Ruiz-Cantero, C.; Coricello, A.; Costa, G.; Lee, S. M.; Son, K. N.; Lombino, J.; Costanzo, G.; Cosentino, G.; Giordano, G.; Pasquinucci, L.; Marrazzo, A.; Aakalu, V. K.; Cobos, E. J.; Alcaro, S.; Amata, E. | |
| Synthesis, in vitro evaluation, and molecular modeling studies of LP2 analogs | 1-gen-2022 | Costanzo, Giuliana; Patamia, Vincenzo; Amata, Emanuele; Rescifina, Antonio; Lorella Pasquinucci, And |