COSTANZO, GIULIANA
COSTANZO, GIULIANA
SCIENZE DEL FARMACO E DELLA SALUTE (DSFS) (Department of Drug and Health Sciences)
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain
2022-01-01 Spoto, Salvatore; Pasquinucci, Lorella Giuseppina; Turnaturi, Rita; Costanzo, Giuliana; Chiechio, Santina; Vicario, Nunzio; Parenti, Rosalba; Marrazzo, Agostino; Amata, Emanuele; Parenti, Carmela
Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands
file da validare2025-01-01 Cosentino, Giuseppe; Dichiara, Maria; Costanzo, Giuliana; Coco, Alessandro; Pasquinucci, Lorella; Marrazzo, Agostino; Rescifina, Antonio; Amata, Emanuele
Design, Synthesis and biological evaluation of hybrid MOR agonist/ HDACi molecules as potential therapeutic agents for chronic pain treatment
2021-01-01 Costanzo, Giuliana; Turnaturi, Rita; Barbaraci, Carla; Marrazzo, Agostino; Pasquinucci, Lorella
Design, synthesis and biological evaluation of MOR agonist/HDACi hybrid compounds: a new potential therapeutic strategy for persistent pain management
2021-01-01 Costanzo, Giuliana; Turnaturi, Rita; Marrazzo, Agostino; Pasquinucci, Lorella
Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management
2022-01-01 Costanzo, Giuliana; Mahmoud, Al-Khrasani; Turnaturi, Rita; Amata, Emanuele; Marrazzo, Agostino; Parenti, Carmela; Pasquinucci, Lorella Giuseppina
Design, Synthesis, and Evaluation of Novel (−)‐cis‐N‐Normetazocine Derivatives: In Vitro and Molecular Modeling Insights
2024-01-01 Costanzo, Giuliana; Coco, Alessandro; Cosentino, Giuseppe; Patamia, Vincenzo; Parenti, Carmela; Amata, Emanuele; Marrazzo, Agostino; Rescifina, Antonio; Pasquinucci, Lorella
Designing drugs optimized for both blood-brain barrier permeation and intra-cerebral partition
file da validare2023-01-01 Dichiara, Maria; Cosentino, Giuseppe; Giordano, Giorgia; Pasquinucci, Lorella; Marrazzo, Agostino; Costanzo, Giuliana; Amata, Emanuele
Development of selective sigma-1 receptor ligands with antiallodynic activity: A focus on piperidine and piperazine scaffolds
2025-01-01 Cosentino, G.; Dichiara, M.; Ambrosio, F. A.; Leotta, C. G.; Costa, G.; Procopio, F.; Costanzo, G.; Raffa, A.; Artacho-Cordon, A.; Ruiz-Cantero, M. C.; Pasquinucci, L.; Marrazzo, A.; Pitari, G. M.; Cobos, E. J.; Alcaro, S.; Amata, E.
Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity
2023-01-01 Dichiara, Maria; Ambrosio Francesca, Alessandra; Lee Sang, Min; Ruiz-Cantero M., Carmen; Lombino, Jessica; Coricello, Adriana; Costa, Giosuè; Shah, Dhara; Costanzo, Giuliana; Pasquinucci, Lorella Giuseppina; Son Kyung, No; Cosentino, Giuseppe; González-Cano, Rafael; Marrazzo, Agostino; Aakalu Vinay, Kumar; Cobos Enrique, J.; Alcaro, Stefano; Amata, Emanuele
From Plant to Chemistry: Sources of Active Opioid Antinociceptive Principles for Medicinal Chemistry and Drug Design
2023-01-01 Turnaturi, R.; Piana, S.; Spoto, S.; Costanzo, G.; Reina, L.; Pasquinucci, L.; Parenti, C.
Hybrid MOR agonist/HDACi molecules as potential antinociceptive multi-target drugs: design, synthesis, and biological evaluation
2022-01-01 Costanzo, Giuliana; Turnaturi, Rita; Marrazzo, Agostino; Amata, Emanuele; Parenti, Carmela; Pasquinucci, Lorella
Hybrid MOR agonist/HDACi molecules as potential new drugs for persistant pain management: design, synthesis and biological evaluation
2021-01-01 Costanzo, Giuliana; Turnaturi, Rita; Marrazzo, Agostino; Pasquinucci, Lorella
Investigation of Tau-Dependent Epigenetic Reprogramming in Alzheimer’s Disease
2024-01-01 Costanzo, G.; Coco, A.; Scarlatti, A.; Siano, G.; Cosentino, G.; Di Primio, C.; Amata, E.; Marrazzo, A.; Rescifina, A.; Pasquinucci, L.
MOR/DOR Dual-Target Approach: 2S-LP2 Effects in Inflammatory and Neuropathic Pain
2022-01-01 Spoto, Salvatore; Pasquinucci, Lorella; Turnaturi, Rita; Marrazzo, Agostino; Amata, Emanuele; Costanzo, Giuliana; Chiechio, Santina; Parenti, Carmela
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands
2023-01-01 Costanzo, Giuliana; Turnaturi, Rita; Parenti, Carmela; Spoto, Salvatore; Piana, Silvia; Dichiara, Maria; Zagni, Chiara; Galambos, Anna Rita; Essmat, Nariman; Marrazzo, Agostino; Amata, Emanuele; Al-Khrasani, Mahmoud; Pasquinucci, Lorella
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics for Pain Treatment
2023-01-01 Costanzo, Giuliana; Vicario, Nunzio; Turnaturi, Rita; Marrazzo, Agostino; Amata, Emanuele; Parenti, Carmela; Pasquinucci, Lorella
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain
2022-01-01 Turnaturi, Rita; Chiechio, Santina; Pasquinucci, Lorella; Spoto, Salvatore; Costanzo, Giuliana; Dichiara, Maria; Piana, Silvia; Grasso, Margherita; Amata, Emanuele; Marrazzo, Agostino; Parenti, Carmela
NOVEL N-NORMETAZOCINE DERIVATIVES WITH SIGMA-1 RECEPTOR ANTAGONIST PROFILE AS POTENTIAL ANALGESICS FOR INFLAMMATORY PAIN MANAGEMENT
file da validare2023-01-01 Costanzo, G.; Cosentino, G.; Patamia, V.; Turnaturi, R.; Parenti, C.; Rescifina, A.; Marrazzo, A.; Amata, E; Pasquinucci, L.
Novel sigma 1-antagonists with cis-(+)-normetazocine scaffold: synthesis, molecular modeling, and antinociceptive effect
file da validare2025-01-01 Costanzo, Giuliana; Cosentino, Giuseppe; Grasso, Margherita; Patamia, Vincenzo; Zuccalà, Sara; Coco, Alessandro; Novello, Elisabetta; Al-Khrasani, Mahmoud; Morrone, Raffaele; Pitari, Gm; Amata, Emanuele; Marrazzo, Agostino; Rescifina, Antonio; Pasquinucci, Lorella Giuseppina; Parenti, Carmela
PET imaging of the opioid system using radioligands: Synthetic approaches and translational applications
file da validare2025-01-01 Reale, Carlo; Costanzo, Giuliana; Cosentino, Giuseppe; Parenti, Carmela; Pasquinucci, Lorella
Titolo | Data di pubblicazione | Autore(i) | File |
---|---|---|---|
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain | 1-gen-2022 | Spoto, Salvatore; Pasquinucci, Lorella Giuseppina; Turnaturi, Rita; Costanzo, Giuliana; Chiechio, Santina; Vicario, Nunzio; Parenti, Rosalba; Marrazzo, Agostino; Amata, Emanuele; Parenti, Carmela | |
Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands | 1-gen-2025 | Cosentino, Giuseppe; Dichiara, Maria; Costanzo, Giuliana; Coco, Alessandro; Pasquinucci, Lorella; Marrazzo, Agostino; Rescifina, Antonio; Amata, Emanuele | file da validare |
Design, Synthesis and biological evaluation of hybrid MOR agonist/ HDACi molecules as potential therapeutic agents for chronic pain treatment | 1-gen-2021 | Costanzo, Giuliana; Turnaturi, Rita; Barbaraci, Carla; Marrazzo, Agostino; Pasquinucci, Lorella | |
Design, synthesis and biological evaluation of MOR agonist/HDACi hybrid compounds: a new potential therapeutic strategy for persistent pain management | 1-gen-2021 | Costanzo, Giuliana; Turnaturi, Rita; Marrazzo, Agostino; Pasquinucci, Lorella | |
Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management | 1-gen-2022 | Costanzo, Giuliana; Mahmoud, Al-Khrasani; Turnaturi, Rita; Amata, Emanuele; Marrazzo, Agostino; Parenti, Carmela; Pasquinucci, Lorella Giuseppina | |
Design, Synthesis, and Evaluation of Novel (−)‐cis‐N‐Normetazocine Derivatives: In Vitro and Molecular Modeling Insights | 1-gen-2024 | Costanzo, Giuliana; Coco, Alessandro; Cosentino, Giuseppe; Patamia, Vincenzo; Parenti, Carmela; Amata, Emanuele; Marrazzo, Agostino; Rescifina, Antonio; Pasquinucci, Lorella | |
Designing drugs optimized for both blood-brain barrier permeation and intra-cerebral partition | 1-gen-2023 | Dichiara, Maria; Cosentino, Giuseppe; Giordano, Giorgia; Pasquinucci, Lorella; Marrazzo, Agostino; Costanzo, Giuliana; Amata, Emanuele | file da validare |
Development of selective sigma-1 receptor ligands with antiallodynic activity: A focus on piperidine and piperazine scaffolds | 1-gen-2025 | Cosentino, G.; Dichiara, M.; Ambrosio, F. A.; Leotta, C. G.; Costa, G.; Procopio, F.; Costanzo, G.; Raffa, A.; Artacho-Cordon, A.; Ruiz-Cantero, M. C.; Pasquinucci, L.; Marrazzo, A.; Pitari, G. M.; Cobos, E. J.; Alcaro, S.; Amata, E. | |
Discovery of AD258 as a Sigma Receptor Ligand with Potent Antiallodynic Activity | 1-gen-2023 | Dichiara, Maria; Ambrosio Francesca, Alessandra; Lee Sang, Min; Ruiz-Cantero M., Carmen; Lombino, Jessica; Coricello, Adriana; Costa, Giosuè; Shah, Dhara; Costanzo, Giuliana; Pasquinucci, Lorella Giuseppina; Son Kyung, No; Cosentino, Giuseppe; González-Cano, Rafael; Marrazzo, Agostino; Aakalu Vinay, Kumar; Cobos Enrique, J.; Alcaro, Stefano; Amata, Emanuele | |
From Plant to Chemistry: Sources of Active Opioid Antinociceptive Principles for Medicinal Chemistry and Drug Design | 1-gen-2023 | Turnaturi, R.; Piana, S.; Spoto, S.; Costanzo, G.; Reina, L.; Pasquinucci, L.; Parenti, C. | |
Hybrid MOR agonist/HDACi molecules as potential antinociceptive multi-target drugs: design, synthesis, and biological evaluation | 1-gen-2022 | Costanzo, Giuliana; Turnaturi, Rita; Marrazzo, Agostino; Amata, Emanuele; Parenti, Carmela; Pasquinucci, Lorella | |
Hybrid MOR agonist/HDACi molecules as potential new drugs for persistant pain management: design, synthesis and biological evaluation | 1-gen-2021 | Costanzo, Giuliana; Turnaturi, Rita; Marrazzo, Agostino; Pasquinucci, Lorella | |
Investigation of Tau-Dependent Epigenetic Reprogramming in Alzheimer’s Disease | 1-gen-2024 | Costanzo, G.; Coco, A.; Scarlatti, A.; Siano, G.; Cosentino, G.; Di Primio, C.; Amata, E.; Marrazzo, A.; Rescifina, A.; Pasquinucci, L. | |
MOR/DOR Dual-Target Approach: 2S-LP2 Effects in Inflammatory and Neuropathic Pain | 1-gen-2022 | Spoto, Salvatore; Pasquinucci, Lorella; Turnaturi, Rita; Marrazzo, Agostino; Amata, Emanuele; Costanzo, Giuliana; Chiechio, Santina; Parenti, Carmela | |
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands | 1-gen-2023 | Costanzo, Giuliana; Turnaturi, Rita; Parenti, Carmela; Spoto, Salvatore; Piana, Silvia; Dichiara, Maria; Zagni, Chiara; Galambos, Anna Rita; Essmat, Nariman; Marrazzo, Agostino; Amata, Emanuele; Al-Khrasani, Mahmoud; Pasquinucci, Lorella | |
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics for Pain Treatment | 1-gen-2023 | Costanzo, Giuliana; Vicario, Nunzio; Turnaturi, Rita; Marrazzo, Agostino; Amata, Emanuele; Parenti, Carmela; Pasquinucci, Lorella | |
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain | 1-gen-2022 | Turnaturi, Rita; Chiechio, Santina; Pasquinucci, Lorella; Spoto, Salvatore; Costanzo, Giuliana; Dichiara, Maria; Piana, Silvia; Grasso, Margherita; Amata, Emanuele; Marrazzo, Agostino; Parenti, Carmela | |
NOVEL N-NORMETAZOCINE DERIVATIVES WITH SIGMA-1 RECEPTOR ANTAGONIST PROFILE AS POTENTIAL ANALGESICS FOR INFLAMMATORY PAIN MANAGEMENT | 1-gen-2023 | Costanzo, G.; Cosentino, G.; Patamia, V.; Turnaturi, R.; Parenti, C.; Rescifina, A.; Marrazzo, A.; Amata, E; Pasquinucci, L. | file da validare |
Novel sigma 1-antagonists with cis-(+)-normetazocine scaffold: synthesis, molecular modeling, and antinociceptive effect | 1-gen-2025 | Costanzo, Giuliana; Cosentino, Giuseppe; Grasso, Margherita; Patamia, Vincenzo; Zuccalà, Sara; Coco, Alessandro; Novello, Elisabetta; Al-Khrasani, Mahmoud; Morrone, Raffaele; Pitari, Gm; Amata, Emanuele; Marrazzo, Agostino; Rescifina, Antonio; Pasquinucci, Lorella Giuseppina; Parenti, Carmela | file da validare |
PET imaging of the opioid system using radioligands: Synthetic approaches and translational applications | 1-gen-2025 | Reale, Carlo; Costanzo, Giuliana; Cosentino, Giuseppe; Parenti, Carmela; Pasquinucci, Lorella | file da validare |