Testicular Choriocarcinoma With an Unusual Clinical Onset: Lessons Learned From This Case Report

Germ cell tumors account for 95% of testicular tumors, in men 15 to 35 years of age. Testicular choriocarcinoma is the rarest and most aggressive form of testicular cancer. The 5-year survival prognosis, for patients, is less than 80%. Diagnosis and pathologic staging are performed by using sonography, computed tomography, or magnetic resonance imaging. Sonography is the primary diagnostic tool that allows for the recognition of a testicular mass, as well as possible abdominal metastases. It ...

Current Status of Minimally Invasive Surgery for Donor Hepatectomy: A Worldwide Survey (A Joint Initiative of the International Laparoscopic Liver Society and the International Living Donor Liver Transplantation Group)

Background: Minimally invasive donor hepatectomy (MIDH) is gaining exponential growth. This study aimed to investigate the global dissemination of MIDH and to identify strategies and barriers to implementing MIDH in centers performing living donor liver transplantation (LDLT). Methods: A web-based survey was distributed to members of the International Laparoscopic Liver Society, the International Living Donor Liver Transplantation Group, and centers performing LDLT identified through a system...

Effect of inclisiran on lipid and mechanical vascular profiles in familial hypercholesterolemia subjects: results from a single lipid center real-world experience

Background and aims: Familial hypercholesterolemia (FH) is characterized by elevated LDL-C and an increased risk of premature cardiovascular events. Inclisiran is a small interfering RNA that inhibits hepatic PCSK9 synthesis and promotes LDL-C clearance by enhancing LDLR expression on hepatocytes. This study aimed to evaluate the efficacy of six-months add-on inclisiran on lipid profile and PWV in FH; furthermore, we investigated the association between LDL-C reduction and PWV variation. Meth...

Nascita, evoluzione e prospettive di due insediamenti rurali di colonizzazione: Borgo Carso e La Bazana