Neuroprotective Agents Against Cell Death In Primary Astroglial And Oligodendroglial Rat Cell Cultures: Role Of Parps Family

PARPs family enzymes play an important role in cell cycle regulation, genome stability, apoptotic cell death(V. Spina Purrello et al. 2008). We show here that, due to the NO binding activity of carnosine, such effect could be attributed to a down-regulation of PARP-1 and PARP-2 expression by carnosine and trehalose treatment under stress conditions. These data suggest that besides their antioxidant role, carnosine and trehalose may also modify the pathways regulated by PARPs. To verify this hypothesis we are investigating the role of these molecules in neurodegenerative disorders.