Noninvasive Early Biomarkers and Chemopreventive Strategies for Oral Cancer and Oral Potentially Malignant Disorders: New Advancements and Future Perspectives

This chapter delves into the cutting-edge field of noninvasive early biomarkers and chemopreventive strategies for oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD). In an era where oral cancers continue to pose a significant global health burden, the need for innovative approaches to early detection and prevention has become paramount. This chapter meticulously examines the latest advancements in noninvasive biomarker technologies, including genomic, proteomic, and metabolomic approaches, which hold promise for accurate and early diagnosis. Moreover, the chapter delves into the emerging landscape of chemopreventive interventions, exploring targeted therapies and immunomodulatory agents that exhibit the potential in halting or retarding the progression of oral malignancies. The pivotal role of chemopreventive strategies is underscored by the need for effective interventions that go beyond traditional therapies. By targeting the molecular pathways implicated in carcinogenesis, chemopreventive agents offer a unique opportunity to intercept disease progression. By synthesizing current research findings and clinical insights, this chapter not only presents a comprehensive overview of the field’s present state but also extrapolates toward the future, envisioning a landscape where personalized medicine and precision interventions play pivotal roles in eradicating the threat of oral cancer and its precursor lesions. As such, this chapter serves as an essential reference for clinicians, researchers, and policymakers invested in advancing the boundaries of oral cancer management and prevention. As research progresses, the synergy between early diagnosis, noninvasive biomarker identification, and chemopreventive therapy is poised to reshape the landscape of OPMD and OSCC management, offering a glimpse of a future where these diseases are no longer insurmountable challenges but rather preventable and manageable conditions.