INTAGLIATA, SEBASTIANO
INTAGLIATA, SEBASTIANO
SCIENZE DEL FARMACO E DELLA SALUTE (DSFS) (Department of Drug and Health Sciences)
[1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT7 receptor
2019-01-01 Romeo, Giuseppe; Salerno, Loredana; Pittalà, Valeria; Candido, Marialuisa; Intagliata, Sebastiano; Amata, Emanuele; Salmona, Mario; Cagnotto, Alfredo; Rescifina, Antonio; Floresta, Giuseppe; Modica, Maria Nunziata
A computer-aided approach to identify novel Leishmania major protein disulfide isomerase inhibitors for treatment of leishmaniasis
file da validare2021-01-01 Ben Khalaf, N.; Pham, S.; Romeo, G.; Abdelghany, S.; Intagliata, S.; Sedillo, P.; Salerno, L.; Gonzales, J.; Fathallah, D. M.; Perkins, D. J.; Hurwitz, I.; Pittala, V.
ATTIVITÀ ANTIOSSIDANTE IN VITRO DI DERIVATI DELL’IDEBENONE
file da validare2017-01-01 Modica, Maria Nunziata; Salerno, Loredana; Intagliata, S; Romeo, Giuseppe; Pittala', Valeria; Panico, Anna Maria; Crascì, L; Puglisi, Giovanni; Montenegro, Lucia
Benzimidazolone-based selective σ2 receptor ligands: Synthesis and pharmacological evaluation
2019-01-01 Intagliata, S.; Alsharif, W. F.; Mesangeau, C.; Fazio, N.; Seminerio, M.; Xu, Y. -T.; Matsumoto, R. R.; Mccurdy, C. R.
Bioanalytical method development and pharmacokinetics of MCI-92, a sigma-1 receptor ligand
file da validare2020-01-01 Popa, R.; Kamble, S. H.; Kanumuri, R. S.; King, T. I.; Berthold, E. C.; Intagliata, S.; Sharma, A.; Mccurdy, C. R.
Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain
2022-01-01 Wilson, Ll; Alleyne, Ar; Eans, So; Cirino, Tj; Stacy, Hm; Mottinelli, M; Intagliata, S; Mccurdy, Cr; Mclaughlin, Jp
Characterization of sigma 1 receptor antagonist CM-304 and its analog, AZ-66: Novel therapeutics against allodynia and induced pain
2019-01-01 Cirino, T. J.; Eans, S. O.; Medina, J. M.; Wilson, L. L.; Mottinelli, M.; Intagliata, S.; Mccurdy, C. R.; Mclaughlin, J. P.
Chromatograpic resolution of phenylethanolic-azole racemic compounds highlighted stereoselective inhibition of heme oxygenase-1 by (R)-enantiomers
2020-01-01 Floresta, G.; Carotti, A.; Ianni, F.; Sorrenti, V.; Intagliata, S.; Rescifina, A.; Salerno, L.; Di Michele, A.; Sardella, R.; Pittala, V.
Combination of heme oxygenase-1 inhibition and sigma receptor modulation for anticancer activity
2021-01-01 Romeo, Giuseppe; Ciaffaglione, Valeria; Amata, Emanuele; Dichiara, Maria; Calabrese, Loredana; Vanella, Luca; Sorrenti, Valeria; Grosso, Salvo; D'Amico, AGATA GRAZIA; D'Agata, Velia; Intagliata, Sebastiano; Salerno, Loredana
Design and synthesis of new homo and hetero bis-piperazinyl-1- propanone derivatives as 5-HT7R selective ligands over 5-HT1AR
2016-01-01 Intagliata, S; Modica, Maria Nunziata; Pittala', Valeria; Salerno, Loredana; Siracusa, Maria Angela; Cagnotto, A; Salmona, M; Romeo, Giuseppe
Design, synthesis, and pharmacological evaluation of NO donor-sigma receptors hybrids for the treatment of cancer
2018-01-01 Dichiara, Maria; Barbaraci, Carla; Gentile, Davide; Intagliata, Sebastiano; Pittalà, Valeria; Arena, Emanuelea; Fraix, Aurore; Farina, Giuseppe; Prezzavento, Orazio; Amata, Emanuele; Marrazzo, Agostino.
Development of New Benzylpiperazine Derivatives as σ1Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects
file da validare2021-01-01 Romeo, G.; Bonanno, F.; Wilson, L. L.; Arena, E.; Modica, M. N.; Pittala, V.; Salerno, L.; Prezzavento, O.; Mclaughlin, J. P.; Intagliata, S.
Discovery of 3-(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligands
file da validare2022-01-01 Elkholy, Nada; Abdelwaly, Ahmad; Mohamed, Karim; Amata, Emanuele; Lombino, Jessica; Cosentino, Giuseppe; Intagliata, Sebastiano; Helal A., Mohamed
Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo
file da validare2020-01-01 Intagliata, S.; Sharma, A.; King, T. I.; Mesangeau, C.; Seminerio, M.; Chin, F. T.; Wilson, L. L.; Matsumoto, R. R.; Mclaughlin, J. P.; Avery, B. A.; Mccurdy, C. R.
Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent in Vitro Antiproliferative Activity
2021-01-01 Fallica, A. N.; Sorrenti, V.; D'Amico, A. G.; Salerno, L.; Romeo, G.; Intagliata, S.; Consoli, V.; Floresta, G.; Rescifina, A.; D'Agata, V.; Vanella, L.; Pittala, V.
Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5-Fluorouracil and Imidazole-Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells
file da validare2023-01-01 Salerno, Loredana; Sorrenti, Valeria; Pittalà, Valeria; Consoli, Valeria; Modica, Maria N; Romeo, Giuseppe; Marrazzo, Agostino; Giuliano, Michela; Zajdel, Paweł; Vanella, Luca; Intagliata, Sebastiano
Divergent cytotoxic and metabolically stimulative functions of sigma-2 receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives
2019-01-01 Nicholson, H. E.; Alsharif, W. F.; Comeau, A. B.; Mesangeau, C.; Intagliata, S.; Mottinelli, M.; Mccurdy, C. R.; Bowen, W. D.
Examination of the Novel Sigma‐1 Receptor Antagonist, SI 1/28, for Antinociceptive and Anti‐Allodynic Efficacy against Multiple Types of Nociception with Fewer Liabilities of Use
2022-01-01 Wilson, L. L.; Eans, S. O.; Ramadan-siraj, I.; Modica, M. N.; Romeo, G.; Intagliata, S.; Mclaughlin, J. P.
Exploring 1-adamantanamine as an alternative amine moiety for metabolically labile azepane ring in newly synthesized benzo[d]thiazol-2(3H)one σ receptor ligands
file da validare2020-01-01 Intagliata, S.; Agha, H.; Kopajtic, T. A.; Katz, J. L.; Kamble, S. H.; Sharma, A.; Avery, B. A.; Mccurdy, C. R.
Ginseng and heme oxygenase-1: The link between an old herb and a new protective system
2019-01-01 Carota, G.; Raffaele, M.; Sorrenti, V.; Salerno, L.; Pittala, V.; Intagliata, S.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| [1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HT7 receptor | 1-gen-2019 | Romeo, Giuseppe; Salerno, Loredana; Pittalà, Valeria; Candido, Marialuisa; Intagliata, Sebastiano; Amata, Emanuele; Salmona, Mario; Cagnotto, Alfredo; Rescifina, Antonio; Floresta, Giuseppe; Modica, Maria Nunziata | |
| A computer-aided approach to identify novel Leishmania major protein disulfide isomerase inhibitors for treatment of leishmaniasis | 1-gen-2021 | Ben Khalaf, N.; Pham, S.; Romeo, G.; Abdelghany, S.; Intagliata, S.; Sedillo, P.; Salerno, L.; Gonzales, J.; Fathallah, D. M.; Perkins, D. J.; Hurwitz, I.; Pittala, V. | file da validare |
| ATTIVITÀ ANTIOSSIDANTE IN VITRO DI DERIVATI DELL’IDEBENONE | 1-gen-2017 | Modica, Maria Nunziata; Salerno, Loredana; Intagliata, S; Romeo, Giuseppe; Pittala', Valeria; Panico, Anna Maria; Crascì, L; Puglisi, Giovanni; Montenegro, Lucia | file da validare |
| Benzimidazolone-based selective σ2 receptor ligands: Synthesis and pharmacological evaluation | 1-gen-2019 | Intagliata, S.; Alsharif, W. F.; Mesangeau, C.; Fazio, N.; Seminerio, M.; Xu, Y. -T.; Matsumoto, R. R.; Mccurdy, C. R. | |
| Bioanalytical method development and pharmacokinetics of MCI-92, a sigma-1 receptor ligand | 1-gen-2020 | Popa, R.; Kamble, S. H.; Kanumuri, R. S.; King, T. I.; Berthold, E. C.; Intagliata, S.; Sharma, A.; Mccurdy, C. R. | file da validare |
| Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain | 1-gen-2022 | Wilson, Ll; Alleyne, Ar; Eans, So; Cirino, Tj; Stacy, Hm; Mottinelli, M; Intagliata, S; Mccurdy, Cr; Mclaughlin, Jp | |
| Characterization of sigma 1 receptor antagonist CM-304 and its analog, AZ-66: Novel therapeutics against allodynia and induced pain | 1-gen-2019 | Cirino, T. J.; Eans, S. O.; Medina, J. M.; Wilson, L. L.; Mottinelli, M.; Intagliata, S.; Mccurdy, C. R.; Mclaughlin, J. P. | |
| Chromatograpic resolution of phenylethanolic-azole racemic compounds highlighted stereoselective inhibition of heme oxygenase-1 by (R)-enantiomers | 1-gen-2020 | Floresta, G.; Carotti, A.; Ianni, F.; Sorrenti, V.; Intagliata, S.; Rescifina, A.; Salerno, L.; Di Michele, A.; Sardella, R.; Pittala, V. | |
| Combination of heme oxygenase-1 inhibition and sigma receptor modulation for anticancer activity | 1-gen-2021 | Romeo, Giuseppe; Ciaffaglione, Valeria; Amata, Emanuele; Dichiara, Maria; Calabrese, Loredana; Vanella, Luca; Sorrenti, Valeria; Grosso, Salvo; D'Amico, AGATA GRAZIA; D'Agata, Velia; Intagliata, Sebastiano; Salerno, Loredana | |
| Design and synthesis of new homo and hetero bis-piperazinyl-1- propanone derivatives as 5-HT7R selective ligands over 5-HT1AR | 1-gen-2016 | Intagliata, S; Modica, Maria Nunziata; Pittala', Valeria; Salerno, Loredana; Siracusa, Maria Angela; Cagnotto, A; Salmona, M; Romeo, Giuseppe | |
| Design, synthesis, and pharmacological evaluation of NO donor-sigma receptors hybrids for the treatment of cancer | 1-gen-2018 | Dichiara, Maria; Barbaraci, Carla; Gentile, Davide; Intagliata, Sebastiano; Pittalà, Valeria; Arena, Emanuelea; Fraix, Aurore; Farina, Giuseppe; Prezzavento, Orazio; Amata, Emanuele; Marrazzo, Agostino. | |
| Development of New Benzylpiperazine Derivatives as σ1Receptor Ligands with in Vivo Antinociceptive and Anti-Allodynic Effects | 1-gen-2021 | Romeo, G.; Bonanno, F.; Wilson, L. L.; Arena, E.; Modica, M. N.; Pittala, V.; Salerno, L.; Prezzavento, O.; Mclaughlin, J. P.; Intagliata, S. | file da validare |
| Discovery of 3-(2-aminoethyl)-thiazolidine-2,4-diones as a novel chemotype of sigma-1 receptor ligands | 1-gen-2022 | Elkholy, Nada; Abdelwaly, Ahmad; Mohamed, Karim; Amata, Emanuele; Lombino, Jessica; Cosentino, Giuseppe; Intagliata, Sebastiano; Helal A., Mohamed | file da validare |
| Discovery of a Highly Selective Sigma-2 Receptor Ligand, 1-(4-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-3-methyl-1H-benzo[d]imidazol-2(3H)-one (CM398), with Drug-Like Properties and Antinociceptive Effects In Vivo | 1-gen-2020 | Intagliata, S.; Sharma, A.; King, T. I.; Mesangeau, C.; Seminerio, M.; Chin, F. T.; Wilson, L. L.; Matsumoto, R. R.; Mclaughlin, J. P.; Avery, B. A.; Mccurdy, C. R. | file da validare |
| Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent in Vitro Antiproliferative Activity | 1-gen-2021 | Fallica, A. N.; Sorrenti, V.; D'Amico, A. G.; Salerno, L.; Romeo, G.; Intagliata, S.; Consoli, V.; Floresta, G.; Rescifina, A.; D'Agata, V.; Vanella, L.; Pittala, V. | |
| Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5-Fluorouracil and Imidazole-Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells | 1-gen-2023 | Salerno, Loredana; Sorrenti, Valeria; Pittalà, Valeria; Consoli, Valeria; Modica, Maria N; Romeo, Giuseppe; Marrazzo, Agostino; Giuliano, Michela; Zajdel, Paweł; Vanella, Luca; Intagliata, Sebastiano | file da validare |
| Divergent cytotoxic and metabolically stimulative functions of sigma-2 receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives | 1-gen-2019 | Nicholson, H. E.; Alsharif, W. F.; Comeau, A. B.; Mesangeau, C.; Intagliata, S.; Mottinelli, M.; Mccurdy, C. R.; Bowen, W. D. | |
| Examination of the Novel Sigma‐1 Receptor Antagonist, SI 1/28, for Antinociceptive and Anti‐Allodynic Efficacy against Multiple Types of Nociception with Fewer Liabilities of Use | 1-gen-2022 | Wilson, L. L.; Eans, S. O.; Ramadan-siraj, I.; Modica, M. N.; Romeo, G.; Intagliata, S.; Mclaughlin, J. P. | |
| Exploring 1-adamantanamine as an alternative amine moiety for metabolically labile azepane ring in newly synthesized benzo[d]thiazol-2(3H)one σ receptor ligands | 1-gen-2020 | Intagliata, S.; Agha, H.; Kopajtic, T. A.; Katz, J. L.; Kamble, S. H.; Sharma, A.; Avery, B. A.; Mccurdy, C. R. | file da validare |
| Ginseng and heme oxygenase-1: The link between an old herb and a new protective system | 1-gen-2019 | Carota, G.; Raffaele, M.; Sorrenti, V.; Salerno, L.; Pittala, V.; Intagliata, S. |