| Nome |
# |
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In-vitro evaluation of a new benzomorphan-based ligand, file dfe4d228-83d3-bb0a-e053-d805fe0a78d9
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467
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|
Simultaneous activation of mu and delta opioid receptors reduces allodynia and astrocytic connexin 43 in an animal model of neuropathic pain, file dfe4d229-e51c-bb0a-e053-d805fe0a78d9
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193
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In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate, file dfe4d229-8e7f-bb0a-e053-d805fe0a78d9
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133
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Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles, file dfe4d228-6ea1-bb0a-e053-d805fe0a78d9
|
108
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Rescue of noradrenergic system as a novel pharmacological strategy in the treatment of chronic pain: Focus on microglia activation, file dfe4d229-ed53-bb0a-e053-d805fe0a78d9
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48
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Synthesis and structure-activity relationships of (–)-cis-N-normetazocine-based LP1 derivatives, file dfe4d229-0274-bb0a-e053-d805fe0a78d9
|
36
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Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain, file 787a4eae-ae28-42e4-9c5b-e6ffe33803c3
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25
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Sigma-2 receptor ligands QSAR model dataset, file dfe4d227-df3b-bb0a-e053-d805fe0a78d9
|
24
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Chronic treatment with fluoxetine induces sex-dependent analgesic effects and modulates HDAC2 and mGlu2 expression in female mice, file dfe4d228-b20e-bb0a-e053-d805fe0a78d9
|
20
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|
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists, file dfe4d228-dc11-bb0a-e053-d805fe0a78d9
|
18
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Connexins in the central nervous system: physiological traits and neuroprotective targets, file dfe4d22c-6b77-bb0a-e053-d805fe0a78d9
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18
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|
Resveratrol-loaded lipid nanocarriers: Correlation between in vitro occlusion factor and in vivo skin hydrating effect, file dfe4d228-9524-bb0a-e053-d805fe0a78d9
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15
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Idebenone: Novel strategies to improve its systemic and local efficacy, file dfe4d228-ac57-bb0a-e053-d805fe0a78d9
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10
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New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands, file 6db428fa-2b5c-4ccb-a8b9-c2dd16f669ab
|
9
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Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and
Antihyperalgesic Activity of Harpagophytum procumbens in Rats., file dfe4d227-0200-bb0a-e053-d805fe0a78d9
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9
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In Vitro Evaluation of Sunscreen Safety: Effects of the Vehicle and Repeated Applications on Skin Permeation from Topical Formulations, file dfe4d228-c1c6-bb0a-e053-d805fe0a78d9
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9
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|
Harpagophytum procumbens
extract potentiates morphine antinociception in neuropathic rats., file dfe4d227-007a-bb0a-e053-d805fe0a78d9
|
8
|
|
Repeated activation of delta opiod receptors counteracts nerve injury-induced
TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain: A
possible correlation with delta opiod receptors-mediated antiallodinic effect., file dfe4d227-a775-bb0a-e053-d805fe0a78d9
|
8
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|
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling, file dfe4d22e-5536-bb0a-e053-d805fe0a78d9
|
8
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Design, synthesis, in vitro evaluation, and molecular modeling studies of N-substituted benzomorphans, analogs of LP2, as novel MOR ligands, file c2cdfff2-b964-4334-90bc-644a48d95784
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7
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HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors, file dfe4d226-ff16-bb0a-e053-d805fe0a78d9
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7
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Inhibition of Cx43 mediates protective effects on hypoxic/reoxygenated human neuroblastoma cells, file dfe4d227-9a6b-bb0a-e053-d805fe0a78d9
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7
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Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization, file dfe4d22b-475e-bb0a-e053-d805fe0a78d9
|
7
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Wilms’ Tumor Gene 1 (WT1) silencing inhibits proliferation of malignant peripheral nerve sheath tumor sNF96.2 cell line., file dfe4d226-ff15-bb0a-e053-d805fe0a78d9
|
6
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Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype, file dfe4d227-95c7-bb0a-e053-d805fe0a78d9
|
6
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|
Influenza del N-sostituente della (–)-cis-N-Normetazocina nella modulazione del profilo funzionale al MOR, DOR e KOR: da agonista ad antagonista attraverso ligandi misti agonisti/antagonisti, file dfe4d229-8dd4-bb0a-e053-d805fe0a78d9
|
6
|
|
Neuroprotective effects of Rosmarinus officinalis L. extract in oxygen glucose deprivation (OGD)-injured human neural-like cells, file dfe4d229-a533-bb0a-e053-d805fe0a78d9
|
6
|
|
Lp1 and lp2: Dual‐target mopr/dopr ligands as drug candidates for persistent pain relief, file dfe4d22e-598b-bb0a-e053-d805fe0a78d9
|
6
|
|
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain, file 27e3a036-d724-4d51-9242-ad75ac53e98b
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5
|
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Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures
and derivatives, file dfe4d227-2e1a-bb0a-e053-d805fe0a78d9
|
5
|
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Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation., file dfe4d227-a560-bb0a-e053-d805fe0a78d9
|
5
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Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands, file dfe4d229-a928-bb0a-e053-d805fe0a78d9
|
5
|
|
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist, file dfe4d22a-eed3-bb0a-e053-d805fe0a78d9
|
5
|
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Solid lipid nanoparticles as carriers for the synthetic opioid lp2: Characterization and in vitro release, file dfe4d22e-ba3d-bb0a-e053-d805fe0a78d9
|
5
|
|
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures, file dfe4d227-b385-bb0a-e053-d805fe0a78d9
|
4
|
|
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures, file dfe4d227-b386-bb0a-e053-d805fe0a78d9
|
4
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|
Synthesis and in vitro opioid receptor studies on benzomorphan-based compounds: LP1, a potent and long-acting antinociceptive, file dfe4d228-8448-bb0a-e053-d805fe0a78d9
|
4
|
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R- ed S-LP2: sintesi, molecular docking e valutazione farmacologica, file dfe4d228-b3d2-bb0a-e053-d805fe0a78d9
|
4
|
|
MOR/DOR targeting: an useful strategy in pain management, file dfe4d229-8a9d-bb0a-e053-d805fe0a78d9
|
4
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|
LP2 e 2S-LP2: agonisti biased dual target MOR/DOR nel trattamento del dolore cronico, file dfe4d229-8efb-bb0a-e053-d805fe0a78d9
|
4
|
|
MOR/DOR targeting: an useful strategy in pain management, file dfe4d229-9745-bb0a-e053-d805fe0a78d9
|
4
|
|
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity, file f9f8dca3-6ec7-4221-9c41-4760b5c358e4
|
4
|
|
A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect, file dfe4d226-f8f4-bb0a-e053-d805fe0a78d9
|
3
|
|
In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia, file dfe4d227-13a0-bb0a-e053-d805fe0a78d9
|
3
|
|
The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation., file dfe4d227-2540-bb0a-e053-d805fe0a78d9
|
3
|
|
Evaluation of N-substituent structural variations in opioid receptor profile of LP1., file dfe4d227-9330-bb0a-e053-d805fe0a78d9
|
3
|
|
The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation., file dfe4d227-b6ec-bb0a-e053-d805fe0a78d9
|
3
|
|
Development of novel LP1-based analogues with enhanced delta opioid receptor profile, file dfe4d228-ae77-bb0a-e053-d805fe0a78d9
|
3
|
|
Tumor necrosis factor-related apoptosis-inducing ligand reduces the expression of the neuroprotective Na+ /Ca2+ exchanger isoform NCX3 in human neuroblastoma SH-SY5Y cells, file dfe4d229-a92e-bb0a-e053-d805fe0a78d9
|
3
|
|
Progress in the development of more effective and safer analgesics for pain management, file dfe4d22a-f2ae-bb0a-e053-d805fe0a78d9
|
3
|
|
Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation, file dfe4d22b-3e00-bb0a-e053-d805fe0a78d9
|
3
|
|
((2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist, file dfe4d22b-3e09-bb0a-e053-d805fe0a78d9
|
3
|
|
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures, file dfe4d227-01d3-bb0a-e053-d805fe0a78d9
|
2
|
|
From NMDA receptor antagonists to discovery of selective σ₂
receptor ligands, file dfe4d227-025b-bb0a-e053-d805fe0a78d9
|
2
|
|
Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia, file dfe4d227-2a5b-bb0a-e053-d805fe0a78d9
|
2
|
|
New benzomorphan derivatives of MPCB as MOP and KOP receptor ligands, file dfe4d227-7d8a-bb0a-e053-d805fe0a78d9
|
2
|
|
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis, file dfe4d228-8510-bb0a-e053-d805fe0a78d9
|
2
|
|
Synthesis and evaluation of haloperidol metabolite II prodrugs as anticancer agents, file dfe4d228-8512-bb0a-e053-d805fe0a78d9
|
2
|
|
Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes, file dfe4d229-c729-bb0a-e053-d805fe0a78d9
|
2
|
|
From plant to bench: natural products as source for analgesic drug development., file dfe4d22b-4d59-bb0a-e053-d805fe0a78d9
|
2
|
|
Multitarget Opioid/Non-opioid Ligands: A Potential Approach in Pain Management, file dfe4d22b-8e63-bb0a-e053-d805fe0a78d9
|
2
|
|
A New LP1 analogue is used to better understand MOR ligand Binding Domain and its mechanisms of activation, file dfe4d22b-ff9a-bb0a-e053-d805fe0a78d9
|
2
|
|
Hybrid MOR agonist/HDACi molecules as potential antinociceptive multi-target drugs: design, synthesis, and biological evaluation, file 1a7a5ca9-a377-47d5-aba0-901964b5cd87
|
1
|
|
Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation, file 3bf57ea2-9319-4da4-a703-6fd1777fef0b
|
1
|
|
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands, file 61713f9d-aa40-4ca6-9f1a-63a80ea247ea
|
1
|
|
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists, file af56fd43-07a1-4236-ad34-51fe9af5fc09
|
1
|
|
Evaluation of N-substitution in 6,7-benzomorphan compounds, file dfe4d226-fc05-bb0a-e053-d805fe0a78d9
|
1
|
|
Multitarget opioid ligands in pain relief: New players in an old game, file dfe4d226-fef7-bb0a-e053-d805fe0a78d9
|
1
|
|
Haloperidol metabolite II prodrug: Asymmetric synthesis and biological evaluation on rat C6 glioma cells, file dfe4d226-ff14-bb0a-e053-d805fe0a78d9
|
1
|
|
Wilms' tumor 1 (WT1) protein expression in human developing tissues, file dfe4d227-0079-bb0a-e053-d805fe0a78d9
|
1
|
|
Selective inhibition of the NOP receptor in the ventrolateral peraqueductal gray attenuates the development and the expression of tolerance to morphine-induced antinociception in rats, file dfe4d227-05d1-bb0a-e053-d805fe0a78d9
|
1
|
|
Synthesis and Resolution of cis (±)-Methyl (1R,2S/1S,2R)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl) cyclopropanecarboxylate [(±)-PPCC)]: New Sigma Receptor Ligands with Neuroprotective Effect, file dfe4d227-05dc-bb0a-e053-d805fe0a78d9
|
1
|
|
Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand., file dfe4d227-0617-bb0a-e053-d805fe0a78d9
|
1
|
|
Supraspinal injection of
Substance P attenuates allodynia and hyperalgesia in a rat model of inflammatory
pain, file dfe4d227-0a62-bb0a-e053-d805fe0a78d9
|
1
|
|
null, file dfe4d227-115c-bb0a-e053-d805fe0a78d9
|
1
|
|
The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain
treatment, file dfe4d227-13b8-bb0a-e053-d805fe0a78d9
|
1
|
|
Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the
ventrolateral periaqueductal gray following mechanical allodynia in chronic pain, file dfe4d227-144f-bb0a-e053-d805fe0a78d9
|
1
|
|
New bifunctional antioxidant/σ1 agonist ligands: preliminary chemico-physical and biological evaluation, file dfe4d227-1717-bb0a-e053-d805fe0a78d9
|
1
|
|
Design and synthesis of new bifunctional sigma-1 selective ligands with antioxidant activity., file dfe4d227-237f-bb0a-e053-d805fe0a78d9
|
1
|
|
Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties, file dfe4d227-2517-bb0a-e053-d805fe0a78d9
|
1
|
|
The Benzomorphan-Based Compound LP1 as Suitable Candidate for Pain Management, file dfe4d227-2855-bb0a-e053-d805fe0a78d9
|
1
|
|
Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain, file dfe4d227-2f4c-bb0a-e053-d805fe0a78d9
|
1
|
|
(+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects, file dfe4d227-3c4f-bb0a-e053-d805fe0a78d9
|
1
|
|
Opioid and sigma receptor studies. New developments in the design of selective sigma ligands, file dfe4d227-7f5f-bb0a-e053-d805fe0a78d9
|
1
|
|
In vitro and in vivo pharmacological evaluation of LP1, a benzomorphan-based compound, file dfe4d228-7f44-bb0a-e053-d805fe0a78d9
|
1
|
|
Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries, file dfe4d228-8416-bb0a-e053-d805fe0a78d9
|
1
|
|
IDEBENONE LOADED LIPID NANOPARTICLES: EVALUATION OF IN VITRO ANTIOXIDANT ACTIVITY AND IN VIVO TOPICAL EFFECTS, file dfe4d228-ad89-bb0a-e053-d805fe0a78d9
|
1
|
|
Dual MOR/DOR agonist benzomorphan-based compounds for pain relief, file dfe4d228-b3c9-bb0a-e053-d805fe0a78d9
|
1
|
|
Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new?, file dfe4d228-bf4f-bb0a-e053-d805fe0a78d9
|
1
|
|
Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review, file dfe4d228-e3c7-bb0a-e053-d805fe0a78d9
|
1
|
|
MOR/DOR targeting mediates neuropathic pain amelioration in chronic constriction injured rats., file dfe4d229-974a-bb0a-e053-d805fe0a78d9
|
1
|
|
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists, file dfe4d22a-f2a8-bb0a-e053-d805fe0a78d9
|
1
|
|
Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review, file dfe4d22b-24ae-bb0a-e053-d805fe0a78d9
|
1
|
| Totale |
1.367 |