IRIS
PARENTI, Carmela
 Distribuzione geografica
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Continente #
NA - Nord America 11.249
EU - Europa 4.916
AS - Asia 4.491
SA - Sud America 710
AF - Africa 696
Continente sconosciuto - Info sul continente non disponibili 451
OC - Oceania 12
Totale 22.525
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Nazione #
US - Stati Uniti d'America 10.829
SG - Singapore 2.242
RU - Federazione Russa 1.408
IT - Italia 1.285
CN - Cina 1.210
IE - Irlanda 610
BR - Brasile 573
UA - Ucraina 527
CI - Costa d'Avorio 375
VN - Vietnam 314
CA - Canada 298
FR - Francia 253
DE - Germania 211
KR - Corea 163
GB - Regno Unito 144
SE - Svezia 138
SN - Senegal 104
NG - Nigeria 103
IN - India 100
BD - Bangladesh 99
JP - Giappone 66
MX - Messico 53
ES - Italia 51
FI - Finlandia 48
PL - Polonia 47
HK - Hong Kong 45
NL - Olanda 41
ID - Indonesia 37
ZA - Sudafrica 37
AR - Argentina 35
IQ - Iraq 34
TR - Turchia 29
VE - Venezuela 26
BE - Belgio 25
UZ - Uzbekistan 25
CO - Colombia 22
AT - Austria 19
PK - Pakistan 19
CH - Svizzera 18
CR - Costa Rica 18
EC - Ecuador 18
KE - Kenya 17
AE - Emirati Arabi Uniti 16
CZ - Repubblica Ceca 16
CL - Cile 15
GR - Grecia 14
DZ - Algeria 12
JM - Giamaica 12
LB - Libano 12
AU - Australia 11
BJ - Benin 10
EG - Egitto 10
HU - Ungheria 10
LT - Lituania 10
MA - Marocco 10
TH - Thailandia 9
JO - Giordania 8
MY - Malesia 8
PE - Perù 8
PY - Paraguay 8
SA - Arabia Saudita 8
HN - Honduras 7
TN - Tunisia 7
AZ - Azerbaigian 6
ET - Etiopia 6
IL - Israele 6
IR - Iran 6
TT - Trinidad e Tobago 6
AL - Albania 5
EU - Europa 5
NP - Nepal 5
OM - Oman 5
PH - Filippine 5
SV - El Salvador 5
BB - Barbados 4
BG - Bulgaria 4
HR - Croazia 4
NO - Norvegia 4
PT - Portogallo 4
RS - Serbia 4
BO - Bolivia 3
DK - Danimarca 3
DO - Repubblica Dominicana 3
PS - Palestinian Territory 3
SK - Slovacchia (Repubblica Slovacca) 3
AM - Armenia 2
AO - Angola 2
GT - Guatemala 2
LV - Lettonia 2
NI - Nicaragua 2
RO - Romania 2
SY - Repubblica araba siriana 2
UY - Uruguay 2
BH - Bahrain 1
BM - Bermuda 1
BW - Botswana 1
BY - Bielorussia 1
BZ - Belize 1
DM - Dominica 1
EE - Estonia 1
Totale 22.059
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Città #
Dallas 1.711
Singapore 1.305
Santa Clara 1.053
Houston 1.030
San Jose 800
Chandler 785
Dublin 606
Ashburn 581
Moscow 575
Jacksonville 499
Chicago 474
Abidjan 375
Catania 357
Boardman 284
Council Bluffs 228
Nanjing 187
Beijing 185
Los Angeles 175
Cambridge 170
Lawrence 170
Andover 169
Hefei 169
Lauterbourg 165
Toronto 164
Seoul 163
Dakar 104
Ho Chi Minh City 97
Civitanova Marche 94
Wilmington 93
New York 90
San Mateo 84
Bremen 83
Des Moines 71
São Paulo 71
Buffalo 69
Hanoi 67
Nanchang 64
Tokyo 57
Rome 56
Columbus 52
The Dalles 51
Shenyang 50
Saint Petersburg 46
Abuja 45
Ottawa 45
Naples 43
Jiaxing 41
Lagos 40
Munich 40
Atlanta 39
Hong Kong 39
Changsha 38
Denver 38
Tianjin 37
Warsaw 36
Montreal 35
Hebei 34
Brooklyn 33
Grafing 32
Phoenix 32
Bari 28
Johannesburg 27
Orem 27
Seattle 26
Brussels 24
Jakarta 22
London 22
Milan 22
Amsterdam 20
Messina 20
Frankfurt am Main 19
Belo Horizonte 18
Chennai 18
Helsinki 18
Palermo 18
Port Harcourt 18
Pune 18
Rio de Janeiro 18
Turku 18
Da Nang 17
Dong Ket 17
Falls Church 17
Washington 17
Baghdad 16
Mexico City 16
Poplar 16
San Giovanni la Punta 16
San José 16
Boston 15
Jinan 15
Ningbo 15
San Francisco 15
Gravina di Catania 14
Haiphong 14
Madrid 14
Norwalk 14
Augusta 13
Mascalucia 12
Paris 12
San Gregorio di Catania 12
Totale 15.040
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Nome #
Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation. 464
Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation 416
NOP RECEPTOR ANTAGONISM IN THE VENTROLATERAL PERIAQUEDUCTAL GRAY ATTENUATES THE DEVELOPMENT OF OPIOID TOLERANCE. 357
((2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist 330
The simultaneous activation of μ- and δ-opioid receptors by (−)-2S-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model 237
Involvement of sigma 2 receptor on motor disorder 213
Neuroprotective effects of Rosmarinus officinalis L. extract in oxygen glucose deprivation (OGD)-injured human neural-like cells 212
Do vitamins halt the COVID-19-evoked pro-inflammatory cytokines involved in the development of neuropathic pain? 202
Design, synthesis, in vitro evaluation, and molecular modeling studies of N-substituted benzomorphans, analogs of LP2, as novel MOR ligands 200
Inhibition of Cx43 mediates protective effects on hypoxic/reoxygenated human neuroblastoma cells 194
Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review 192
(+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects 191
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis 185
A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect 180
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain 179
ANTIALLODINIC AND ANTIHYPERALGESIC EFFECTS OF LP1, AN OPIOID MULTITARGET LIGAND, IN INFLAMMATORY AND NEUROPATHIC PAIN STATES 170
Connexins in the central nervous system: physiological traits and neuroprotective targets 168
R- ed S-LP2: sintesi, molecular docking e valutazione farmacologica 168
Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. 165
Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review 164
CHF5074 protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro 162
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 162
Dual MOR/DOR agonist benzomorphan-based compounds for pain relief 160
In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate 160
Influenza del N-sostituente della (–)-cis-N-Normetazocina nella modulazione del profilo funzionale al MOR, DOR e KOR: da agonista ad antagonista attraverso ligandi misti agonisti/antagonisti 156
Intercellular communication and ion channels in neuropathic pain chronicization 156
Chronic treatment with fluoxetine induces sex-dependent analgesic effects and modulates HDAC2 and mGlu2 expression in female mice 155
THE BENZOMORPHAN-BASED COMPOUND LP1 AS A MULTITARGET OPIOID LIGAND FOR CHRONIC PAIN TREATMENT 153
(+)-Mr200 derivatives: modifications on the amino moiety. In vitro and in vivo pharmacological evaluation 151
Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain 150
Development of novel LP1-based analogues with enhanced delta opioid receptor profile 150
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists 147
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling 146
Central and peripheral control by endogenous opioid peptides of gastric protection in stressed-rats 145
Dual-target ligands and pain: our experience 144
Apoptotic effects of (±) MRJF4 in prostate cancer cells 143
Effect of supraspinal Nocistatin on nociceptin/OrphaninFQ antagonism of selective opioid analgesia 142
The benzomorphan-based compound LP1 is a central acting MOR agonist/DOR antagonist suitable for chronic pain treatment 142
An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain 142
MOR/DOR targeting: an useful strategy in pain management 142
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 141
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 141
Novel sigma 1-antagonists with cis-(+)-normetazocine scaffold: synthesis, molecular modeling, and antinociceptive effect 140
Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain 140
From plant to bench: natural products as source for analgesic drug development. 139
The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation. 138
A New LP1 analogue is used to better understand MOR ligand Binding Domain and its mechanisms of activation 138
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 137
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists 137
Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia 135
LP2 e 2S-LP2: agonisti biased dual target MOR/DOR nel trattamento del dolore cronico 135
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity 134
Tumor necrosis factor-related apoptosis-inducing ligand reduces the expression of the neuroprotective Na+ /Ca2+ exchanger isoform NCX3 in human neuroblastoma SH-SY5Y cells 134
Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new? 134
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain 133
Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management 133
Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype 133
Multitarget Opioid/Non-opioid Ligands: A Potential Approach in Pain Management 132
Sigma-2 receptor ligands QSAR model dataset 131
Harpagophytum procumbens extract potentiates morphine antinociception in neuropathic rats. 130
Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization 130
Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats. 129
Neuroprotective effect of the new sigma receptor ligands cis-(+) and cis-(–)-PPCC 129
Repeated activation of delta opiod receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opiod receptors-mediated antiallodinic effect. 129
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain 128
Effect of CCK-8 on analgesia induced by cold-restraint stress in the rat 128
Antiallodinic and antihyperalgesic effects of LP1, an opioid multitarget ligand, in inflammatory and neurophatic pain states 128
Central and peripheral involvement of endogenous opioid peptides in gastric protection in stressed rats 128
ANTIALLODYNIC AND ANTIHYPERALGESIC EFFECTS OF INTRAPLANTAR NOCISTATIN AND (±)-J 113397 IN INFLAMMATORY PAIN 127
From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design 125
The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment 122
Different in vitro activity of flurbiprofen and its enantimers on human articular cartilage 122
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands 120
Multitarget opioid ligands in pain relief: New players in an old game 120
Studio aerobiologico e incidenza di pollinosi nella popolazione acese 120
Antiallodynic and antihyperalgesic effects of intraplantar nocistatin and (+/-)-J113397 in inflammatory pain 118
Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain 117
Evaluation of N-substituent structural variations in opioid receptor profile of LP1. 117
In vitro and in vivo pharmacological evaluation of LP1, a benzomorphan-based compound 116
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures 115
Progress in the development of more effective and safer analgesics for pain management 114
Wilms’ Tumor Gene 1 (WT1) silencing inhibits proliferation of malignant peripheral nerve sheath tumor sNF96.2 cell line 112
In-vitro evaluation of a new benzomorphan-based ligand 112
Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes 112
Effects of dinorphin 1-13 on hyperalgesia induced by interleukin-1bera in the rat 110
Evaluation of N-substitution in 6,7-benzomorphan compounds 110
Idebenone: Novel strategies to improve its systemic and local efficacy 110
Effect of arachidonic acid on pituitary immunoreactive B-endorphin levels in the rat 109
The Benzomorphan-Based Compound LP1 as Suitable Candidate for Pain Management 109
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 109
Rescue of noradrenergic system as a novel pharmacological strategy in the treatment of chronic pain: Focus on microglia activation 109
Hybrid MOR agonist/HDACi molecules as potential antinociceptive multi-target drugs: design, synthesis, and biological evaluation 107
Wilms' tumor 1 (WT1) protein expression in human developing tissues 107
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands 106
HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors 106
Synthesis and in vitro opioid receptor studies on benzomorphan-based compounds: LP1, a potent and long-acting antinociceptive 106
Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles 105
Prevention of stress-induced gastric ulcers by mu- and delta-opioid agonists in the rat 103
Pain management: new long-acting opioid ligands 103
Design, Synthesis, and Evaluation of Novel (−)‐cis‐N‐Normetazocine Derivatives: In Vitro and Molecular Modeling Insights 102
Totale 14.939
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Categoria #
all - tutte 72.312
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 72.312
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.013 0 0 0 38 207 16 184 55 120 23 55 315
2022/20232.384 193 127 46 289 208 374 8 433 501 45 98 62
2023/20241.258 82 217 76 60 68 286 48 76 2 33 217 93
2024/20254.039 67 736 210 236 865 476 196 185 242 318 241 267
2025/20268.705 518 333 1.883 444 1.298 1.606 974 171 456 526 303 193
2026/20271.235 369 321 189 356 0 0 0 0 0 0 0 0
Totale 22.525