IRIS
PARENTI, Carmela
 Distribuzione geografica
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Continente #
NA - Nord America 9.939
EU - Europa 4.655
AS - Asia 4.385
AF - Africa 695
SA - Sud America 664
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 5
Totale 20.355
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Nazione #
US - Stati Uniti d'America 9.615
SG - Singapore 2.215
RU - Federazione Russa 1.406
CN - Cina 1.195
IT - Italia 1.096
IE - Irlanda 610
BR - Brasile 552
UA - Ucraina 527
CI - Costa d'Avorio 375
VN - Vietnam 310
CA - Canada 249
FR - Francia 243
DE - Germania 209
KR - Corea 163
GB - Regno Unito 132
SE - Svezia 107
SN - Senegal 104
NG - Nigeria 103
IN - India 99
JP - Giappone 66
BD - Bangladesh 55
MX - Messico 52
FI - Finlandia 48
PL - Polonia 47
ES - Italia 43
HK - Hong Kong 39
NL - Olanda 39
ZA - Sudafrica 37
ID - Indonesia 36
AR - Argentina 34
IQ - Iraq 34
TR - Turchia 28
BE - Belgio 25
UZ - Uzbekistan 25
VE - Venezuela 20
AT - Austria 19
PK - Pakistan 19
CH - Svizzera 18
KE - Kenya 17
CZ - Repubblica Ceca 16
AE - Emirati Arabi Uniti 15
EC - Ecuador 15
GR - Grecia 14
CL - Cile 13
CO - Colombia 12
DZ - Algeria 12
AU - Australia 11
LB - Libano 11
BJ - Benin 10
EG - Egitto 10
HU - Ungheria 10
MA - Marocco 10
LT - Lituania 9
TH - Thailandia 9
SA - Arabia Saudita 8
CR - Costa Rica 7
PE - Perù 7
AZ - Azerbaigian 6
ET - Etiopia 6
IL - Israele 6
IR - Iran 6
JO - Giordania 6
MY - Malesia 6
PY - Paraguay 6
TN - Tunisia 6
AL - Albania 5
EU - Europa 5
NP - Nepal 5
OM - Oman 5
PH - Filippine 5
BG - Bulgaria 4
HR - Croazia 4
NO - Norvegia 4
RS - Serbia 4
BB - Barbados 3
BO - Bolivia 3
DK - Danimarca 3
DO - Repubblica Dominicana 3
JM - Giamaica 3
PS - Palestinian Territory 3
PT - Portogallo 3
SV - El Salvador 3
AO - Angola 2
LV - Lettonia 2
SK - Slovacchia (Repubblica Slovacca) 2
SY - Repubblica araba siriana 2
TT - Trinidad e Tobago 2
UY - Uruguay 2
AM - Armenia 1
BH - Bahrain 1
BW - Botswana 1
BY - Bielorussia 1
EE - Estonia 1
GE - Georgia 1
GP - Guadalupe 1
KW - Kuwait 1
KZ - Kazakistan 1
LI - Liechtenstein 1
LK - Sri Lanka 1
LY - Libia 1
Totale 20.347
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Città #
Dallas 1.694
Singapore 1.303
Houston 1.027
Santa Clara 1.013
Chandler 784
Dublin 606
Moscow 574
San Jose 532
Ashburn 511
Jacksonville 496
Chicago 465
Abidjan 375
Catania 336
Boardman 284
Nanjing 187
Beijing 179
Cambridge 170
Lawrence 170
Andover 169
Hefei 169
Lauterbourg 165
Seoul 163
Toronto 159
Los Angeles 152
Dakar 104
Council Bluffs 99
Ho Chi Minh City 96
Civitanova Marche 94
Wilmington 93
San Mateo 84
Bremen 83
Des Moines 71
New York 69
Hanoi 66
Buffalo 65
São Paulo 65
Nanchang 64
Tokyo 57
Columbus 52
The Dalles 51
Shenyang 50
Saint Petersburg 46
Abuja 45
Ottawa 42
Rome 42
Jiaxing 41
Lagos 40
Munich 40
Changsha 38
Tianjin 37
Warsaw 36
Hebei 34
Hong Kong 33
Denver 32
Grafing 32
Naples 31
Brooklyn 28
Johannesburg 27
Montreal 27
Atlanta 25
Brussels 24
Orem 24
Jakarta 22
Amsterdam 20
London 20
Seattle 20
Frankfurt am Main 19
Belo Horizonte 18
Chennai 18
Helsinki 18
Port Harcourt 18
Rio de Janeiro 18
Turku 18
Da Nang 17
Dong Ket 17
Falls Church 17
Messina 17
Pune 17
Baghdad 16
Phoenix 16
Poplar 16
Jinan 15
Mexico City 15
Ningbo 15
Washington 15
Haiphong 14
Madrid 14
Milan 14
Norwalk 14
San Giovanni la Punta 14
Augusta 13
Boston 12
Palermo 12
Paris 12
San Gregorio di Catania 12
Stockholm 12
Tashkent 12
Lahore 11
Lappeenranta 11
Mascalucia 11
Totale 14.260
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Nome #
Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation. 453
Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation 410
NOP RECEPTOR ANTAGONISM IN THE VENTROLATERAL PERIAQUEDUCTAL GRAY ATTENUATES THE DEVELOPMENT OF OPIOID TOLERANCE. 333
((2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist 320
The simultaneous activation of μ- and δ-opioid receptors by (−)-2S-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model 223
Involvement of sigma 2 receptor on motor disorder 206
Neuroprotective effects of Rosmarinus officinalis L. extract in oxygen glucose deprivation (OGD)-injured human neural-like cells 201
Design, synthesis, in vitro evaluation, and molecular modeling studies of N-substituted benzomorphans, analogs of LP2, as novel MOR ligands 194
Do vitamins halt the COVID-19-evoked pro-inflammatory cytokines involved in the development of neuropathic pain? 193
Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review 183
(+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects 183
Inhibition of Cx43 mediates protective effects on hypoxic/reoxygenated human neuroblastoma cells 180
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis 174
A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect 173
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain 168
Connexins in the central nervous system: physiological traits and neuroprotective targets 164
ANTIALLODINIC AND ANTIHYPERALGESIC EFFECTS OF LP1, AN OPIOID MULTITARGET LIGAND, IN INFLAMMATORY AND NEUROPATHIC PAIN STATES 159
R- ed S-LP2: sintesi, molecular docking e valutazione farmacologica 157
Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review 155
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 152
Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. 150
Influenza del N-sostituente della (–)-cis-N-Normetazocina nella modulazione del profilo funzionale al MOR, DOR e KOR: da agonista ad antagonista attraverso ligandi misti agonisti/antagonisti 150
CHF5074 protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro 147
Chronic treatment with fluoxetine induces sex-dependent analgesic effects and modulates HDAC2 and mGlu2 expression in female mice 145
Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain 144
Dual MOR/DOR agonist benzomorphan-based compounds for pain relief 142
Development of novel LP1-based analogues with enhanced delta opioid receptor profile 142
Intercellular communication and ion channels in neuropathic pain chronicization 142
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling 140
(+)-Mr200 derivatives: modifications on the amino moiety. In vitro and in vivo pharmacological evaluation 139
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists 139
MOR/DOR targeting: an useful strategy in pain management 135
Apoptotic effects of (±) MRJF4 in prostate cancer cells 133
A New LP1 analogue is used to better understand MOR ligand Binding Domain and its mechanisms of activation 133
Effect of supraspinal Nocistatin on nociceptin/OrphaninFQ antagonism of selective opioid analgesia 132
Central and peripheral control by endogenous opioid peptides of gastric protection in stressed-rats 131
From plant to bench: natural products as source for analgesic drug development. 131
An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain 130
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists 130
LP2 e 2S-LP2: agonisti biased dual target MOR/DOR nel trattamento del dolore cronico 130
The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation. 129
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 129
Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain 129
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain 128
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 128
Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia 127
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity 126
Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management 126
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 126
Dual-target ligands and pain: our experience 125
Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats. 125
Effect of CCK-8 on analgesia induced by cold-restraint stress in the rat 125
Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization 125
Neuroprotective effect of the new sigma receptor ligands cis-(+) and cis-(–)-PPCC 123
In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate 123
Sigma-2 receptor ligands QSAR model dataset 122
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain 121
ANTIALLODYNIC AND ANTIHYPERALGESIC EFFECTS OF INTRAPLANTAR NOCISTATIN AND (±)-J 113397 IN INFLAMMATORY PAIN 121
Antiallodinic and antihyperalgesic effects of LP1, an opioid multitarget ligand, in inflammatory and neurophatic pain states 121
Tumor necrosis factor-related apoptosis-inducing ligand reduces the expression of the neuroprotective Na+ /Ca2+ exchanger isoform NCX3 in human neuroblastoma SH-SY5Y cells 121
Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype 120
Novel sigma 1-antagonists with cis-(+)-normetazocine scaffold: synthesis, molecular modeling, and antinociceptive effect 119
Central and peripheral involvement of endogenous opioid peptides in gastric protection in stressed rats 119
Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new? 119
Repeated activation of delta opiod receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opiod receptors-mediated antiallodinic effect. 118
Studio aerobiologico e incidenza di pollinosi nella popolazione acese 117
Multitarget Opioid/Non-opioid Ligands: A Potential Approach in Pain Management 117
From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design 115
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands 115
Antiallodynic and antihyperalgesic effects of intraplantar nocistatin and (+/-)-J113397 in inflammatory pain 113
Different in vitro activity of flurbiprofen and its enantimers on human articular cartilage 113
Harpagophytum procumbens extract potentiates morphine antinociception in neuropathic rats. 113
The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment 111
In vitro and in vivo pharmacological evaluation of LP1, a benzomorphan-based compound 111
Progress in the development of more effective and safer analgesics for pain management 109
Multitarget opioid ligands in pain relief: New players in an old game 108
THE BENZOMORPHAN-BASED COMPOUND LP1 AS A MULTITARGET OPIOID LIGAND FOR CHRONIC PAIN TREATMENT 108
The benzomorphan-based compound LP1 is a central acting MOR agonist/DOR antagonist suitable for chronic pain treatment 108
Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain 108
In-vitro evaluation of a new benzomorphan-based ligand 107
Wilms’ Tumor Gene 1 (WT1) silencing inhibits proliferation of malignant peripheral nerve sheath tumor sNF96.2 cell line 106
Evaluation of N-substituent structural variations in opioid receptor profile of LP1. 106
Effects of dinorphin 1-13 on hyperalgesia induced by interleukin-1bera in the rat 105
Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes 105
Hybrid MOR agonist/HDACi molecules as potential antinociceptive multi-target drugs: design, synthesis, and biological evaluation 102
Effect of arachidonic acid on pituitary immunoreactive B-endorphin levels in the rat 102
Evaluation of N-substitution in 6,7-benzomorphan compounds 102
The Benzomorphan-Based Compound LP1 as Suitable Candidate for Pain Management 102
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 102
Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles 101
Synthesis and in vitro opioid receptor studies on benzomorphan-based compounds: LP1, a potent and long-acting antinociceptive 101
HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors 100
Wilms' tumor 1 (WT1) protein expression in human developing tissues 99
Pain management: new long-acting opioid ligands 99
Prevention of stress-induced gastric ulcers by mu- and delta-opioid agonists in the rat 98
Rescue of noradrenergic system as a novel pharmacological strategy in the treatment of chronic pain: Focus on microglia activation 98
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures 97
Idebenone: Novel strategies to improve its systemic and local efficacy 96
Synthesis and structure-activity relationships of (–)-cis-N-normetazocine-based LP1 derivatives 96
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands 94
Totale 13.925
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Categoria #
all - tutte 61.549
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 61.549
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021236 0 0 0 0 0 0 0 0 0 0 163 73
2021/20221.363 160 175 15 38 207 16 184 55 120 23 55 315
2022/20232.384 193 127 46 289 208 374 8 433 501 45 98 62
2023/20241.258 82 217 76 60 68 286 48 76 2 33 217 93
2024/20254.039 67 736 210 236 865 476 196 185 242 318 241 267
2025/20268.213 518 333 1.883 444 1.298 1.606 974 171 456 526 4 0
Totale 20.798