IRIS
PARENTI, Carmela
 Distribuzione geografica
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Continente #
NA - Nord America 9.007
EU - Europa 2.987
AS - Asia 2.600
AF - Africa 522
SA - Sud America 510
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 5
Totale 15.642
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Nazione #
US - Stati Uniti d'America 8.756
SG - Singapore 1.153
IT - Italia 1.020
CN - Cina 1.018
IE - Irlanda 615
UA - Ucraina 536
BR - Brasile 459
CI - Costa d'Avorio 374
CA - Canada 226
DE - Germania 188
RU - Federazione Russa 188
SN - Senegal 103
SE - Svezia 99
KR - Corea 88
GB - Regno Unito 77
IN - India 59
VN - Vietnam 57
JP - Giappone 55
FR - Francia 45
FI - Finlandia 36
ES - Italia 29
BE - Belgio 25
BD - Bangladesh 24
NL - Olanda 22
ID - Indonesia 21
UZ - Uzbekistan 20
PL - Polonia 19
HK - Hong Kong 18
AT - Austria 17
CH - Svizzera 17
MX - Messico 17
IQ - Iraq 15
AR - Argentina 14
CZ - Repubblica Ceca 14
TR - Turchia 14
ZA - Sudafrica 12
AU - Australia 10
EC - Ecuador 10
GR - Grecia 10
PK - Pakistan 9
MA - Marocco 8
AE - Emirati Arabi Uniti 7
CO - Colombia 7
HU - Ungheria 7
IR - Iran 7
LB - Libano 7
VE - Venezuela 7
DZ - Algeria 6
TH - Thailandia 6
BG - Bulgaria 5
EG - Egitto 5
EU - Europa 5
IL - Israele 5
PE - Perù 5
AL - Albania 4
CL - Cile 4
KE - Kenya 4
NG - Nigeria 4
NO - Norvegia 4
SA - Arabia Saudita 4
AZ - Azerbaigian 3
TN - Tunisia 3
BB - Barbados 2
DK - Danimarca 2
LT - Lituania 2
NP - Nepal 2
UY - Uruguay 2
AO - Angola 1
BO - Bolivia 1
CR - Costa Rica 1
DO - Repubblica Dominicana 1
EE - Estonia 1
ET - Etiopia 1
GE - Georgia 1
GP - Guadalupe 1
HR - Croazia 1
JM - Giamaica 1
JO - Giordania 1
KZ - Kazakistan 1
LI - Liechtenstein 1
LK - Sri Lanka 1
MY - Malesia 1
NZ - Nuova Zelanda 1
OM - Oman 1
PS - Palestinian Territory 1
PT - Portogallo 1
PY - Paraguay 1
RO - Romania 1
SK - Slovacchia (Repubblica Slovacca) 1
SL - Sierra Leone 1
SV - El Salvador 1
TL - Timor Orientale 1
TT - Trinidad e Tobago 1
Totale 15.642
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Città #
Dallas 2.130
Houston 1.018
Santa Clara 1.010
Chandler 794
Singapore 689
Dublin 611
Jacksonville 513
Chicago 466
Abidjan 374
Catania 325
Boardman 289
Ashburn 272
Nanjing 190
Hefei 175
Cambridge 173
Lawrence 173
Andover 171
Toronto 159
Beijing 115
Dakar 103
Civitanova Marche 94
Wilmington 94
Seoul 88
San Mateo 87
Bremen 83
Des Moines 71
Council Bluffs 70
Nanchang 65
Los Angeles 58
Columbus 52
Shenyang 52
The Dalles 51
Tokyo 48
Saint Petersburg 46
São Paulo 46
Jiaxing 42
Ottawa 42
Rome 42
Changsha 40
Munich 39
Tianjin 38
Hebei 34
Grafing 32
Naples 31
New York 27
Brussels 24
Ho Chi Minh City 19
Moscow 19
Turku 18
Dong Ket 17
Falls Church 17
Jakarta 17
Pune 17
Seattle 17
Brooklyn 16
Hong Kong 16
Rio de Janeiro 16
Jinan 15
Ningbo 15
Norwalk 15
Messina 14
San Giovanni la Punta 14
Augusta 13
Helsinki 13
Washington 13
Belo Horizonte 12
Hanoi 11
Mascalucia 11
Zhengzhou 11
Campinas 10
Paternò 10
Atlanta 9
Kunming 9
Leawood 9
Madrid 9
Milan 9
Montreal 9
Salerno 9
Salvador 9
San Francisco 9
Ann Arbor 8
Fremont 8
Fuzhou 8
Liberty Lake 8
London 8
Palermo 8
Porto Alegre 8
Tappahannock 8
Tashkent 8
Warsaw 8
Amsterdam 7
Brno 7
Budapest 7
Charlotte 7
East Stroudsburg 7
Johannesburg 7
Mumbai 7
Phoenix 7
Siracusa 7
Ardabil 6
Totale 11.742
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Nome #
Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation. 432
From Plant to Chemistry: Sources of Active Opioid Antinociceptive Principles for Medicinal Chemistry and Drug Design 430
Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation 391
NOP RECEPTOR ANTAGONISM IN THE VENTROLATERAL PERIAQUEDUCTAL GRAY ATTENUATES THE DEVELOPMENT OF OPIOID TOLERANCE. 312
((2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist 265
The simultaneous activation of μ- and δ-opioid receptors by (−)-2S-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model 186
Involvement of sigma 2 receptor on motor disorder 181
Do vitamins halt the COVID-19-evoked pro-inflammatory cytokines involved in the development of neuropathic pain? 164
Neuroprotective effects of Rosmarinus officinalis L. extract in oxygen glucose deprivation (OGD)-injured human neural-like cells 155
Design, synthesis, in vitro evaluation, and molecular modeling studies of N-substituted benzomorphans, analogs of LP2, as novel MOR ligands 148
Inhibition of Cx43 mediates protective effects on hypoxic/reoxygenated human neuroblastoma cells 136
(+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects 132
Influenza del N-sostituente della (–)-cis-N-Normetazocina nella modulazione del profilo funzionale al MOR, DOR e KOR: da agonista ad antagonista attraverso ligandi misti agonisti/antagonisti 131
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain 124
Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review 123
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis 122
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 120
R- ed S-LP2: sintesi, molecular docking e valutazione farmacologica 117
CHF5074 protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro 115
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists 114
A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect 109
Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. 107
Connexins in the central nervous system: physiological traits and neuroprotective targets 107
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 107
ANTIALLODINIC AND ANTIHYPERALGESIC EFFECTS OF LP1, AN OPIOID MULTITARGET LIGAND, IN INFLAMMATORY AND NEUROPATHIC PAIN STATES 105
LP2 e 2S-LP2: agonisti biased dual target MOR/DOR nel trattamento del dolore cronico 105
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists 103
From plant to bench: natural products as source for analgesic drug development. 103
Intercellular communication and ion channels in neuropathic pain chronicization 103
Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization 102
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling 102
Studio aerobiologico e incidenza di pollinosi nella popolazione acese 100
Sigma-2 receptor ligands QSAR model dataset 100
Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review 100
In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate 99
Development of novel LP1-based analogues with enhanced delta opioid receptor profile 98
Chronic treatment with fluoxetine induces sex-dependent analgesic effects and modulates HDAC2 and mGlu2 expression in female mice 98
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 96
Central and peripheral control by endogenous opioid peptides of gastric protection in stressed-rats 96
The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation. 94
(+)-Mr200 derivatives: modifications on the amino moiety. In vitro and in vivo pharmacological evaluation 93
Dual MOR/DOR agonist benzomorphan-based compounds for pain relief 93
Apoptotic effects of (±) MRJF4 in prostate cancer cells 93
Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain 91
The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment 91
Wilms’ Tumor Gene 1 (WT1) silencing inhibits proliferation of malignant peripheral nerve sheath tumor sNF96.2 cell line 91
Tumor necrosis factor-related apoptosis-inducing ligand reduces the expression of the neuroprotective Na+ /Ca2+ exchanger isoform NCX3 in human neuroblastoma SH-SY5Y cells 91
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain 90
Effect of supraspinal Nocistatin on nociceptin/OrphaninFQ antagonism of selective opioid analgesia 90
Effect of CCK-8 on analgesia induced by cold-restraint stress in the rat 90
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 90
Multitarget opioid ligands in pain relief: New players in an old game 89
Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype 88
Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new? 88
Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management 87
An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain 87
Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia 87
MOR/DOR targeting: an useful strategy in pain management 87
Effects of dinorphin 1-13 on hyperalgesia induced by interleukin-1bera in the rat 86
The benzomorphan-based compound LP1 is a central acting MOR agonist/DOR antagonist suitable for chronic pain treatment 86
Multitarget Opioid/Non-opioid Ligands: A Potential Approach in Pain Management 86
Prevention of stress-induced gastric ulcers by mu- and delta-opioid agonists in the rat. 85
Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats. 85
Neuroprotective effect of the new sigma receptor ligands cis-(+) and cis-(–)-PPCC 85
ANTIALLODYNIC AND ANTIHYPERALGESIC EFFECTS OF INTRAPLANTAR NOCISTATIN AND (±)-J 113397 IN INFLAMMATORY PAIN 85
A New LP1 analogue is used to better understand MOR ligand Binding Domain and its mechanisms of activation 85
Evaluation of N-substituent structural variations in opioid receptor profile of LP1. 85
Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes 85
The Benzomorphan-Based Compound LP1 as Suitable Candidate for Pain Management 84
Wilms' tumor 1 (WT1) protein expression in human developing tissues 82
Antiallodinic and antihyperalgesic effects of LP1, an opioid multitarget ligand, in inflammatory and neurophatic pain states 82
Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain 82
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity 79
In vitro and in vivo pharmacological evaluation of LP1, a benzomorphan-based compound 79
Antiallodynic and antihyperalgesic effects of intraplantar nocistatin and (+/-)-J113397 in inflammatory pain 79
Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles 79
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 79
Progress in the development of more effective and safer analgesics for pain management 79
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain 78
Repeated activation of delta opiod receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opiod receptors-mediated antiallodinic effect. 78
Rescue of noradrenergic system as a novel pharmacological strategy in the treatment of chronic pain: Focus on microglia activation 78
Central and peripheral involvement of endogenous opioid peptides in gastric protection in stressed rats 77
Different in vitro activity of flurbiprofen and its enantimers on human articular cartilage 75
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands 74
Stress-induced changes in the thermic effects of cholecystokinin in the rat 74
Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain 74
THE BENZOMORPHAN-BASED COMPOUND LP1 AS A MULTITARGET OPIOID LIGAND FOR CHRONIC PAIN TREATMENT 74
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures 74
Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries 74
Supraspinal injection of Substance P attenuates allodynia and hyperalgesia in a rat model of inflammatory pain 73
Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain 73
Inhibition of pain response in the formalin test by naloxone in normal- or cold-.restrained-rats 72
The blockade of NOP receptor in the vlPAG reduces the development of tolerance to opioid-induced antinociception in rats 72
In-vitro evaluation of a new benzomorphan-based ligand 72
Synthesis and structure-activity relationships of (–)-cis-N-normetazocine-based LP1 derivatives 72
From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design 71
HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors 71
Idebenone: Novel strategies to improve its systemic and local efficacy 71
Synthesis and in vitro opioid receptor studies on benzomorphan-based compounds: LP1, a potent and long-acting antinociceptive 70
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands 69
Totale 10.821
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Categoria #
all - tutte 52.715
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 52.715
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021846 0 0 0 34 294 35 106 8 110 16 170 73
2021/20221.382 163 178 15 38 210 16 186 56 123 23 56 318
2022/20232.419 196 127 46 291 214 378 8 439 512 45 101 62
2023/20241.265 82 218 78 62 68 286 48 76 2 33 218 94
2024/20254.084 67 747 214 236 877 480 196 188 243 321 243 272
2025/20263.345 527 340 2.336 142 0 0 0 0 0 0 0 0
Totale 16.085