IRIS
PARENTI, Carmela
 Distribuzione geografica
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Continente #
NA - Nord America 10.252
EU - Europa 4.709
AS - Asia 4.453
AF - Africa 695
SA - Sud America 664
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 5
Totale 20.790
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Nazione #
US - Stati Uniti d'America 9.910
SG - Singapore 2.238
RU - Federazione Russa 1.408
CN - Cina 1.202
IT - Italia 1.141
IE - Irlanda 610
BR - Brasile 552
UA - Ucraina 527
CI - Costa d'Avorio 375
VN - Vietnam 310
CA - Canada 258
FR - Francia 243
DE - Germania 209
KR - Corea 163
GB - Regno Unito 134
SE - Svezia 107
SN - Senegal 104
NG - Nigeria 103
IN - India 99
BD - Bangladesh 87
JP - Giappone 66
MX - Messico 53
FI - Finlandia 48
ES - Italia 47
PL - Polonia 47
HK - Hong Kong 43
NL - Olanda 39
ZA - Sudafrica 37
ID - Indonesia 36
AR - Argentina 34
IQ - Iraq 34
TR - Turchia 28
BE - Belgio 25
UZ - Uzbekistan 25
VE - Venezuela 20
AT - Austria 19
PK - Pakistan 19
CH - Svizzera 18
KE - Kenya 17
AE - Emirati Arabi Uniti 16
CZ - Repubblica Ceca 16
EC - Ecuador 15
GR - Grecia 14
CL - Cile 13
CO - Colombia 12
DZ - Algeria 12
LB - Libano 12
AU - Australia 11
BJ - Benin 10
EG - Egitto 10
HU - Ungheria 10
LT - Lituania 10
MA - Marocco 10
CR - Costa Rica 9
TH - Thailandia 9
SA - Arabia Saudita 8
PE - Perù 7
AZ - Azerbaigian 6
ET - Etiopia 6
IL - Israele 6
IR - Iran 6
JO - Giordania 6
MY - Malesia 6
PY - Paraguay 6
TN - Tunisia 6
AL - Albania 5
EU - Europa 5
JM - Giamaica 5
NP - Nepal 5
OM - Oman 5
PH - Filippine 5
BG - Bulgaria 4
HR - Croazia 4
NO - Norvegia 4
RS - Serbia 4
SV - El Salvador 4
BB - Barbados 3
BO - Bolivia 3
DK - Danimarca 3
DO - Repubblica Dominicana 3
PS - Palestinian Territory 3
PT - Portogallo 3
AO - Angola 2
LV - Lettonia 2
SK - Slovacchia (Repubblica Slovacca) 2
SY - Repubblica araba siriana 2
TT - Trinidad e Tobago 2
UY - Uruguay 2
AM - Armenia 1
BH - Bahrain 1
BM - Bermuda 1
BW - Botswana 1
BY - Bielorussia 1
BZ - Belize 1
EE - Estonia 1
GE - Georgia 1
GP - Guadalupe 1
GT - Guatemala 1
KW - Kuwait 1
KZ - Kazakistan 1
Totale 20.779
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Città #
Dallas 1.697
Singapore 1.303
Santa Clara 1.032
Houston 1.029
Chandler 784
San Jose 680
Dublin 606
Moscow 575
Ashburn 528
Jacksonville 497
Chicago 466
Abidjan 375
Catania 342
Boardman 284
Nanjing 187
Beijing 180
Cambridge 170
Lawrence 170
Andover 169
Hefei 169
Lauterbourg 165
Seoul 163
Los Angeles 162
Toronto 160
Dakar 104
Council Bluffs 101
Ho Chi Minh City 96
Civitanova Marche 94
Wilmington 93
San Mateo 84
Bremen 83
New York 76
Des Moines 71
Buffalo 68
Hanoi 66
São Paulo 65
Nanchang 64
Tokyo 57
Columbus 52
The Dalles 51
Shenyang 50
Rome 46
Saint Petersburg 46
Abuja 45
Ottawa 43
Jiaxing 41
Lagos 40
Munich 40
Changsha 38
Hong Kong 37
Tianjin 37
Warsaw 36
Hebei 34
Naples 33
Denver 32
Grafing 32
Brooklyn 29
Montreal 29
Atlanta 27
Johannesburg 27
Brussels 24
Orem 24
Jakarta 22
London 21
Amsterdam 20
Seattle 20
Frankfurt am Main 19
Phoenix 19
Belo Horizonte 18
Chennai 18
Helsinki 18
Port Harcourt 18
Rio de Janeiro 18
Turku 18
Da Nang 17
Dong Ket 17
Falls Church 17
Messina 17
Pune 17
Baghdad 16
Mexico City 16
Milan 16
Poplar 16
San Giovanni la Punta 16
Jinan 15
Ningbo 15
Washington 15
Haiphong 14
Madrid 14
Norwalk 14
Augusta 13
Palermo 13
Boston 12
Paris 12
San Gregorio di Catania 12
Stockholm 12
Tashkent 12
Lahore 11
Lappeenranta 11
Mascalucia 11
Totale 14.508
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Nome #
Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation. 455
Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation 412
NOP RECEPTOR ANTAGONISM IN THE VENTROLATERAL PERIAQUEDUCTAL GRAY ATTENUATES THE DEVELOPMENT OF OPIOID TOLERANCE. 350
((2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist 321
The simultaneous activation of μ- and δ-opioid receptors by (−)-2S-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model 229
Involvement of sigma 2 receptor on motor disorder 207
Neuroprotective effects of Rosmarinus officinalis L. extract in oxygen glucose deprivation (OGD)-injured human neural-like cells 203
Do vitamins halt the COVID-19-evoked pro-inflammatory cytokines involved in the development of neuropathic pain? 196
Design, synthesis, in vitro evaluation, and molecular modeling studies of N-substituted benzomorphans, analogs of LP2, as novel MOR ligands 195
Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review 186
Inhibition of Cx43 mediates protective effects on hypoxic/reoxygenated human neuroblastoma cells 185
(+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects 185
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis 176
A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect 174
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain 171
Connexins in the central nervous system: physiological traits and neuroprotective targets 164
ANTIALLODINIC AND ANTIHYPERALGESIC EFFECTS OF LP1, AN OPIOID MULTITARGET LIGAND, IN INFLAMMATORY AND NEUROPATHIC PAIN STATES 162
R- ed S-LP2: sintesi, molecular docking e valutazione farmacologica 159
Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review 158
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 154
CHF5074 protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro 153
Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. 153
Influenza del N-sostituente della (–)-cis-N-Normetazocina nella modulazione del profilo funzionale al MOR, DOR e KOR: da agonista ad antagonista attraverso ligandi misti agonisti/antagonisti 152
Intercellular communication and ion channels in neuropathic pain chronicization 151
Dual MOR/DOR agonist benzomorphan-based compounds for pain relief 148
Chronic treatment with fluoxetine induces sex-dependent analgesic effects and modulates HDAC2 and mGlu2 expression in female mice 148
(+)-Mr200 derivatives: modifications on the amino moiety. In vitro and in vivo pharmacological evaluation 146
Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain 145
Development of novel LP1-based analogues with enhanced delta opioid receptor profile 144
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling 142
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists 141
MOR/DOR targeting: an useful strategy in pain management 138
Apoptotic effects of (±) MRJF4 in prostate cancer cells 137
Dual-target ligands and pain: our experience 136
Effect of supraspinal Nocistatin on nociceptin/OrphaninFQ antagonism of selective opioid analgesia 136
Central and peripheral control by endogenous opioid peptides of gastric protection in stressed-rats 135
From plant to bench: natural products as source for analgesic drug development. 135
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 133
A New LP1 analogue is used to better understand MOR ligand Binding Domain and its mechanisms of activation 133
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 133
An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain 132
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists 132
Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain 132
The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation. 131
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 131
Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia 131
LP2 e 2S-LP2: agonisti biased dual target MOR/DOR nel trattamento del dolore cronico 131
Novel sigma 1-antagonists with cis-(+)-normetazocine scaffold: synthesis, molecular modeling, and antinociceptive effect 129
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity 129
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain 129
Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management 129
Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization 127
Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats. 126
Effect of CCK-8 on analgesia induced by cold-restraint stress in the rat 126
Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype 126
ANTIALLODYNIC AND ANTIHYPERALGESIC EFFECTS OF INTRAPLANTAR NOCISTATIN AND (±)-J 113397 IN INFLAMMATORY PAIN 125
In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate 125
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain 124
Neuroprotective effect of the new sigma receptor ligands cis-(+) and cis-(–)-PPCC 124
Sigma-2 receptor ligands QSAR model dataset 124
Antiallodinic and antihyperalgesic effects of LP1, an opioid multitarget ligand, in inflammatory and neurophatic pain states 124
Central and peripheral involvement of endogenous opioid peptides in gastric protection in stressed rats 124
Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new? 124
Tumor necrosis factor-related apoptosis-inducing ligand reduces the expression of the neuroprotective Na+ /Ca2+ exchanger isoform NCX3 in human neuroblastoma SH-SY5Y cells 123
Multitarget Opioid/Non-opioid Ligands: A Potential Approach in Pain Management 121
Repeated activation of delta opiod receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opiod receptors-mediated antiallodinic effect. 121
Studio aerobiologico e incidenza di pollinosi nella popolazione acese 118
From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design 116
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands 116
The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment 115
THE BENZOMORPHAN-BASED COMPOUND LP1 AS A MULTITARGET OPIOID LIGAND FOR CHRONIC PAIN TREATMENT 115
Antiallodynic and antihyperalgesic effects of intraplantar nocistatin and (+/-)-J113397 in inflammatory pain 114
Different in vitro activity of flurbiprofen and its enantimers on human articular cartilage 114
Harpagophytum procumbens extract potentiates morphine antinociception in neuropathic rats. 114
Multitarget opioid ligands in pain relief: New players in an old game 111
In vitro and in vivo pharmacological evaluation of LP1, a benzomorphan-based compound 111
The benzomorphan-based compound LP1 is a central acting MOR agonist/DOR antagonist suitable for chronic pain treatment 110
Progress in the development of more effective and safer analgesics for pain management 110
Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain 109
Evaluation of N-substituent structural variations in opioid receptor profile of LP1. 109
Effects of dinorphin 1-13 on hyperalgesia induced by interleukin-1bera in the rat 108
In-vitro evaluation of a new benzomorphan-based ligand 108
Wilms’ Tumor Gene 1 (WT1) silencing inhibits proliferation of malignant peripheral nerve sheath tumor sNF96.2 cell line 107
Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes 106
Effect of arachidonic acid on pituitary immunoreactive B-endorphin levels in the rat 105
The Benzomorphan-Based Compound LP1 as Suitable Candidate for Pain Management 105
Hybrid MOR agonist/HDACi molecules as potential antinociceptive multi-target drugs: design, synthesis, and biological evaluation 104
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 104
HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors 102
Wilms' tumor 1 (WT1) protein expression in human developing tissues 102
Evaluation of N-substitution in 6,7-benzomorphan compounds 102
Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles 102
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures 102
Synthesis and in vitro opioid receptor studies on benzomorphan-based compounds: LP1, a potent and long-acting antinociceptive 101
Rescue of noradrenergic system as a novel pharmacological strategy in the treatment of chronic pain: Focus on microglia activation 101
Pain management: new long-acting opioid ligands 100
Prevention of stress-induced gastric ulcers by mu- and delta-opioid agonists in the rat 99
Synthesis and structure-activity relationships of (–)-cis-N-normetazocine-based LP1 derivatives 98
Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands 97
Idebenone: Novel strategies to improve its systemic and local efficacy 97
Totale 14.213
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Categoria #
all - tutte 65.212
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 65.212
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202173 0 0 0 0 0 0 0 0 0 0 0 73
2021/20221.363 160 175 15 38 207 16 184 55 120 23 55 315
2022/20232.384 193 127 46 289 208 374 8 433 501 45 98 62
2023/20241.258 82 217 76 60 68 286 48 76 2 33 217 93
2024/20254.039 67 736 210 236 865 476 196 185 242 318 241 267
2025/20268.650 518 333 1.883 444 1.298 1.606 974 171 456 526 303 138
Totale 21.235