IRIS
PARENTI, Carmela
 Distribuzione geografica
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Continente #
NA - Nord America 7.915
EU - Europa 2.966
AS - Asia 2.466
SA - Sud America 442
AF - Africa 430
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 5
Totale 14.235
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Nazione #
US - Stati Uniti d'America 7.669
SG - Singapore 1.140
IT - Italia 1.006
CN - Cina 962
IE - Irlanda 615
UA - Ucraina 536
BR - Brasile 404
CI - Costa d'Avorio 283
CA - Canada 226
DE - Germania 188
RU - Federazione Russa 185
SN - Senegal 103
SE - Svezia 99
KR - Corea 81
GB - Regno Unito 77
IN - India 56
JP - Giappone 48
FR - Francia 44
VN - Vietnam 38
FI - Finlandia 36
ES - Italia 28
BE - Belgio 25
NL - Olanda 22
BD - Bangladesh 21
PL - Polonia 19
UZ - Uzbekistan 19
AT - Austria 17
CH - Svizzera 17
CZ - Repubblica Ceca 14
IQ - Iraq 14
MX - Messico 13
TR - Turchia 12
ZA - Sudafrica 12
AR - Argentina 11
ID - Indonesia 11
AU - Australia 10
GR - Grecia 10
HK - Hong Kong 9
PK - Pakistan 9
MA - Marocco 8
AE - Emirati Arabi Uniti 7
HU - Ungheria 7
IR - Iran 7
LB - Libano 7
VE - Venezuela 7
CO - Colombia 6
DZ - Algeria 6
EC - Ecuador 5
EU - Europa 5
TH - Thailandia 5
AL - Albania 4
EG - Egitto 4
IL - Israele 4
KE - Kenya 4
NG - Nigeria 4
NO - Norvegia 4
SA - Arabia Saudita 4
AZ - Azerbaigian 3
BG - Bulgaria 3
PE - Perù 3
TN - Tunisia 3
BB - Barbados 2
CL - Cile 2
DK - Danimarca 2
LT - Lituania 2
NP - Nepal 2
UY - Uruguay 2
AO - Angola 1
BO - Bolivia 1
CR - Costa Rica 1
DO - Repubblica Dominicana 1
EE - Estonia 1
ET - Etiopia 1
GE - Georgia 1
HR - Croazia 1
JM - Giamaica 1
JO - Giordania 1
KZ - Kazakistan 1
LI - Liechtenstein 1
LK - Sri Lanka 1
NZ - Nuova Zelanda 1
OM - Oman 1
PS - Palestinian Territory 1
PT - Portogallo 1
PY - Paraguay 1
RO - Romania 1
SK - Slovacchia (Repubblica Slovacca) 1
SL - Sierra Leone 1
SV - El Salvador 1
TL - Timor Orientale 1
TT - Trinidad e Tobago 1
Totale 14.235
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Città #
Dallas 1.068
Houston 1.018
Santa Clara 1.001
Chandler 794
Singapore 689
Dublin 611
Jacksonville 513
Chicago 466
Catania 317
Boardman 289
Abidjan 283
Ashburn 262
Nanjing 190
Cambridge 173
Lawrence 173
Andover 171
Hefei 159
Toronto 159
Beijing 115
Dakar 103
Civitanova Marche 94
Wilmington 94
San Mateo 87
Bremen 83
Seoul 81
Des Moines 71
Council Bluffs 70
Nanchang 65
Los Angeles 58
Columbus 52
Shenyang 52
The Dalles 51
Saint Petersburg 46
Jiaxing 42
Ottawa 42
Rome 42
São Paulo 41
Tokyo 41
Changsha 40
Munich 39
Tianjin 38
Hebei 34
Grafing 32
Naples 31
New York 27
Brussels 24
Moscow 19
Turku 18
Dong Ket 17
Falls Church 17
Pune 17
Seattle 17
Brooklyn 16
Rio de Janeiro 16
Jinan 15
Ningbo 15
Norwalk 15
Messina 14
San Giovanni la Punta 14
Augusta 13
Helsinki 13
Washington 13
Belo Horizonte 11
Mascalucia 11
Zhengzhou 11
Jakarta 10
Paternò 10
Atlanta 9
Hanoi 9
Ho Chi Minh City 9
Kunming 9
Leawood 9
Madrid 9
Montreal 9
Salerno 9
San Francisco 9
Ann Arbor 8
Campinas 8
Fremont 8
Fuzhou 8
Liberty Lake 8
London 8
Palermo 8
Porto Alegre 8
Salvador 8
Tappahannock 8
Warsaw 8
Amsterdam 7
Brno 7
Budapest 7
Charlotte 7
East Stroudsburg 7
Hong Kong 7
Johannesburg 7
Milan 7
Mumbai 7
Phoenix 7
Siracusa 7
Tashkent 7
Ardabil 6
Totale 10.492
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Nome #
Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation. 425
From Plant to Chemistry: Sources of Active Opioid Antinociceptive Principles for Medicinal Chemistry and Drug Design 419
Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation 382
NOP RECEPTOR ANTAGONISM IN THE VENTROLATERAL PERIAQUEDUCTAL GRAY ATTENUATES THE DEVELOPMENT OF OPIOID TOLERANCE. 303
((2S)-N-2-methoxy-2-phenylethyl-6,7-benzomorphan compound (2S-LP2): Discovery of a biased mu/delta opioid receptor agonist 235
Involvement of sigma 2 receptor on motor disorder 172
The simultaneous activation of μ- and δ-opioid receptors by (−)-2S-LP2 rescues allodynia with the contribution of TGF-β1 signaling in a rat chronic constriction injury model 169
Do vitamins halt the COVID-19-evoked pro-inflammatory cytokines involved in the development of neuropathic pain? 159
Neuroprotective effects of Rosmarinus officinalis L. extract in oxygen glucose deprivation (OGD)-injured human neural-like cells 148
Design, synthesis, in vitro evaluation, and molecular modeling studies of N-substituted benzomorphans, analogs of LP2, as novel MOR ligands 137
Influenza del N-sostituente della (–)-cis-N-Normetazocina nella modulazione del profilo funzionale al MOR, DOR e KOR: da agonista ad antagonista attraverso ligandi misti agonisti/antagonisti 124
Inhibition of Cx43 mediates protective effects on hypoxic/reoxygenated human neuroblastoma cells 122
(+)-and (−)-Phenazocine enantiomers: evaluation of their dual opioid agonist/σ1 antagonist properties and antinociceptive effects 115
Exploiting the Power of Stereochemistry in Drug Action: 3-[(2S,6S,11S)-8-Hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl]-N-phenylpropanamide as Potent Sigma-1 Receptor Antagonist 113
R- ed S-LP2: sintesi, molecular docking e valutazione farmacologica 110
Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis 110
A new Sigma-1 Receptor antagonist in Chronic Pain Treatment: (+)-2R/S-LP2 effects in inflammatory and neuropathic pain 108
Novel N-Substituted Benzomorphan-Based Compounds: From MOR-Agonist/DOR-Antagonist to Biased/Unbiased MOR Agonists 105
Synthesis, in vitro and in vivo characterization of new benzoxazole and benzothiazole-based sigma receptor ligands 104
Synthesis and Structure-Activity Relationships of LP1 Derivatives: N-Methyl-N-phenylethylamino Analogues as Novel MOR Agonists 101
From plant to bench: natural products as source for analgesic drug development. 101
CHF5074 protects SH-SY5Y human neuronal-like cells from amyloidbeta 25-35 and tumor necrosis factor related apoptosis inducing ligand toxicity in vitro 100
Benzomorphan skeleton, a versatile scaffold for different targets: A comprehensive review 100
Connexins in the central nervous system: physiological traits and neuroprotective targets 99
LP2 e 2S-LP2: agonisti biased dual target MOR/DOR nel trattamento del dolore cronico 98
Intercellular communication and ion channels in neuropathic pain chronicization 96
Studio aerobiologico e incidenza di pollinosi nella popolazione acese 95
Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization 95
ANTIALLODINIC AND ANTIHYPERALGESIC EFFECTS OF LP1, AN OPIOID MULTITARGET LIGAND, IN INFLAMMATORY AND NEUROPATHIC PAIN STATES 94
Sigma-2 receptor ligands QSAR model dataset 93
Development of novel LP1-based analogues with enhanced delta opioid receptor profile 91
In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate 91
The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation. 89
A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect 89
Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand. 89
The Multimodal MOPr/DOPr Agonist LP2 Reduces Allodynia in Chronic Constriction Injured Rats by Rescue of TGF-β1 Signalling 89
Chronic treatment with fluoxetine induces sex-dependent analgesic effects and modulates HDAC2 and mGlu2 expression in female mice 88
Central and peripheral control by endogenous opioid peptides of gastric protection in stressed-rats 87
Mu and Delta Opioid Receptor Targeting Reduces Connexin 43-Based Heterocellular Coupling during Neuropathic Pain 86
The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment 86
Wilms’ Tumor Gene 1 (WT1) silencing inhibits proliferation of malignant peripheral nerve sheath tumor sNF96.2 cell line 86
Dual MOR/DOR agonist benzomorphan-based compounds for pain relief 86
Benzomorphan scaffold for opioid analgesics and pharmacological tools development: A comprehensive review 86
Effect of CCK-8 on analgesia induced by cold-restraint stress in the rat 83
The benzomorphan-based compound LP1 is a central acting MOR agonist/DOR antagonist suitable for chronic pain treatment 83
Novel Sigma-1 receptor antagonists: From opioids to small molecules: What is new? 83
Effects of dinorphin 1-13 on hyperalgesia induced by interleukin-1bera in the rat 82
Multitarget opioid ligands in pain relief: New players in an old game 82
Prevention of stress-induced gastric ulcers by mu- and delta-opioid agonists in the rat. 81
Ischemic tolerance modulates TRAIL expression and its receptors and generates a neuroprotected phenotype 81
Apoptotic effects of (±) MRJF4 in prostate cancer cells 81
Tumor necrosis factor-related apoptosis-inducing ligand reduces the expression of the neuroprotective Na+ /Ca2+ exchanger isoform NCX3 in human neuroblastoma SH-SY5Y cells 81
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 80
Activity of profens as racemic (R and S) enantiomers in human condrocytes and cartilage 80
Sigma-1 Receptor Inhibition Reduces Mechanical Allodynia and Modulate Neuroinflammation in Chronic Neuropathic Pain 79
The Benzomorphan-Based Compound LP1 as Suitable Candidate for Pain Management 79
Evaluation of N-substituent structural variations in opioid receptor profile of LP1. 79
Wilms' tumor 1 (WT1) protein expression in human developing tissues 78
Effect of supraspinal Nocistatin on nociceptin/OrphaninFQ antagonism of selective opioid analgesia 78
(+)-Mr200 derivatives: modifications on the amino moiety. In vitro and in vivo pharmacological evaluation 78
Neuroprotective effect of the new sigma receptor ligands cis-(+) and cis-(–)-PPCC 78
Design, synthesis, and biological evaluation of new hybrid MOR agonist/HDACi compounds: an innovative approach for persistent pain management 77
Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats. 77
Multitarget Opioid/Non-opioid Ligands: A Potential Approach in Pain Management 77
MOR/DOR targeting: an useful strategy in pain management 77
Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain 76
Preclinical evidence of enhanced analgesic activity of duloxetine complexed with succinyl-β-cyclodextrin: A comparative study with cyclodextrin complexes 76
In vitro and in vivo pharmacological evaluation of LP1, a benzomorphan-based compound 75
Repeated activation of delta opiod receptors counteracts nerve injury-induced TNF-α up-regulation in the sciatic nerve of rats with neuropathic pain: A possible correlation with delta opiod receptors-mediated antiallodinic effect. 75
Novel N-normetazocine Derivatives with Opioid Agonist/Sigma-1 Receptor Antagonist Profile as Potential Analgesics in Inflammatory Pain 73
Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia 73
Discovery of first novel sigma/HDACi dual-ligands with a potent in vitro antiproliferative activity 72
Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles 72
Progress in the development of more effective and safer analgesics for pain management 72
Effects of a Selective Sigma 1 Antagonist Compound on Inflammatory Pain 71
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives 71
THE BENZOMORPHAN-BASED COMPOUND LP1 AS A MULTITARGET OPIOID LIGAND FOR CHRONIC PAIN TREATMENT 70
Role of the Nrf2/HO-1 axis in bronchopulmonary dysplasia and hyperoxic lung injuries 70
Rescue of noradrenergic system as a novel pharmacological strategy in the treatment of chronic pain: Focus on microglia activation 70
Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain 69
ANTIALLODYNIC AND ANTIHYPERALGESIC EFFECTS OF INTRAPLANTAR NOCISTATIN AND (±)-J 113397 IN INFLAMMATORY PAIN 69
An LP1 analogue, selective MOR agonist with a peculiar pharmacological profile, used to scrutiny the ligand binding domain 69
A New LP1 analogue is used to better understand MOR ligand Binding Domain and its mechanisms of activation 69
Synthesis and in vitro opioid receptor studies on benzomorphan-based compounds: LP1, a potent and long-acting antinociceptive 69
Stress-induced changes in the thermic effects of cholecystokinin in the rat 68
The blockade of NOP receptor in the vlPAG reduces the development of tolerance to opioid-induced antinociception in rats 68
Antiallodinic and antihyperalgesic effects of LP1, an opioid multitarget ligand, in inflammatory and neurophatic pain states 68
In-vitro evaluation of a new benzomorphan-based ligand 68
The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures 67
Different in vitro activity of flurbiprofen and its enantimers on human articular cartilage 67
New Insights into the Opioid Analgesic Profile of cis-(-)-N-Normetazocine-derived Ligands 66
effetti dell'orfaninaFQ sull'analgesia da oppioidi nel ratto 66
Inhibition of pain response in the formalin test by naloxone in normal- or cold-.restrained-rats 66
Synthesis and structure-activity relationships of (–)-cis-N-normetazocine-based LP1 derivatives 66
Supraspinal injection of Substance P attenuates allodynia and hyperalgesia in a rat model of inflammatory pain 65
Prevention of stress-induced gastric ulcers by m- and d-opioid agonists in the rat 65
HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors 65
Antiallodynic and antihyperalgesic effects of intraplantar nocistatin and (+/-)-J113397 in inflammatory pain 65
INVOLVEMENT OF ENDOGENOUS OPIOIDS IN THE ANALGESIC EFFECT OF SUBSTANCE P AT SUPRASPINAL LEVEL 65
Harpagophytum procumbens extract potentiates morphine antinociception in neuropathic rats. 65
Totale 9.950
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Categoria #
all - tutte 49.665
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 49.665
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021962 0 0 116 34 294 35 106 8 110 16 170 73
2021/20221.382 163 178 15 38 210 16 186 56 123 23 56 318
2022/20232.419 196 127 46 291 214 378 8 439 512 45 101 62
2023/20241.265 82 218 78 62 68 286 48 76 2 33 218 94
2024/20254.084 67 747 214 236 877 480 196 188 243 321 243 272
2025/20261.938 527 340 1.071 0 0 0 0 0 0 0 0 0
Totale 14.678