The effects of intraperitoneal and intracerebroventricular administration of mu- and delta- selective opioid receptor agonists (DAGO and DPDPE, respectively) ongastric lesions, were investigated in cold-restraint-stressed rats. DAGO andDPDPE, peripherally and centrally administered, induced a significant gastricprotection. Naloxone prevented the effects of both opioids whereas naltrindoleprevented the gastric protection induced by DPDPE but not that by DAGO. Theresults suggest that mu- and delta-opioid agonists prevent gastric damage inducedby stress through an involvement of both central and peripheral mu- anddelta-opioid receptor subtypes.
Prevention of stress-induced gastric ulcers by mu- and delta-opioid agonists in the rat
PARENTI, Carmela
1993-01-01
Abstract
The effects of intraperitoneal and intracerebroventricular administration of mu- and delta- selective opioid receptor agonists (DAGO and DPDPE, respectively) ongastric lesions, were investigated in cold-restraint-stressed rats. DAGO andDPDPE, peripherally and centrally administered, induced a significant gastricprotection. Naloxone prevented the effects of both opioids whereas naltrindoleprevented the gastric protection induced by DPDPE but not that by DAGO. Theresults suggest that mu- and delta-opioid agonists prevent gastric damage inducedby stress through an involvement of both central and peripheral mu- anddelta-opioid receptor subtypes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
