OBJECTIVE AND DESIGN: The sigma 1 (σ1) receptor, which is widely distributed inthe CNS in areas that are known to be important for pain control, may play a rolein persistent pain characterized by the hypersensitivity of nociceptivetransmission. Here, we investigated the effect of σ1 blockade in an inflammatory pain model.TREATMENT AND METHODS: An intraplantar injection of carrageenan (2 %) was used toinduce paw inflammation. The effects of the σ1 antagonist (+)-MR200, givensubcutaneously at a dose of 0.1, 0.25, 0.5,1, 1.5, and 2 mg/kg prior to injectionof carrageenan, on inflammatory pain and inflammation were assessed. Mechanicalallodynia with von Frey filaments, thermal hyperalgesia with the plantar test andedema evaluation with a plethysmometer were measured. Intergroup comparisons wereassessed by one- or two-way analysis of variance when appropriate, followed bypost-hoc tests (Dunnett's test for one-way or Bonferroni for two-way ANOVA).RESULTS: (+)-MR200 dose-dependently prevented allodynia and hyperalgesia induced by carrageenan. Furthermore, it reduced paw edema with a significant inhibitionpercentage of 37.82 % at 3 h after carrageenan treatment.CONCLUSIONS: The blockade of the σ1 receptor with the selective antagonist(+)-MR200 may contribute to the suppression of the typical symptoms ofinflammatory pain.

The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation.

PARENTI, Carmela;MARRAZZO, Agostino;ARICO', GIUSEPPINA;PARENTI, Rosalba;PASQUINUCCI, Lorella Giuseppina;RONSISVALLE, SIMONE;SCOTO, Giovanna Maria
2014-01-01

Abstract

OBJECTIVE AND DESIGN: The sigma 1 (σ1) receptor, which is widely distributed inthe CNS in areas that are known to be important for pain control, may play a rolein persistent pain characterized by the hypersensitivity of nociceptivetransmission. Here, we investigated the effect of σ1 blockade in an inflammatory pain model.TREATMENT AND METHODS: An intraplantar injection of carrageenan (2 %) was used toinduce paw inflammation. The effects of the σ1 antagonist (+)-MR200, givensubcutaneously at a dose of 0.1, 0.25, 0.5,1, 1.5, and 2 mg/kg prior to injectionof carrageenan, on inflammatory pain and inflammation were assessed. Mechanicalallodynia with von Frey filaments, thermal hyperalgesia with the plantar test andedema evaluation with a plethysmometer were measured. Intergroup comparisons wereassessed by one- or two-way analysis of variance when appropriate, followed bypost-hoc tests (Dunnett's test for one-way or Bonferroni for two-way ANOVA).RESULTS: (+)-MR200 dose-dependently prevented allodynia and hyperalgesia induced by carrageenan. Furthermore, it reduced paw edema with a significant inhibitionpercentage of 37.82 % at 3 h after carrageenan treatment.CONCLUSIONS: The blockade of the σ1 receptor with the selective antagonist(+)-MR200 may contribute to the suppression of the typical symptoms ofinflammatory pain.
Allodynia; Hyperalgesia; Inflammation
File in questo prodotto:
File Dimensione Formato  
Parenti • Agostino Marrazzo • Giuseppina Arico`.pdf

non disponibili

Dimensione 555.58 kB
Formato Adobe PDF
555.58 kB Adobe PDF   Visualizza/Apri
The antagonistic effect of the sigma 1.pdf

non disponibili

Tipologia: Versione Editoriale (PDF)
Dimensione 668.06 kB
Formato Adobe PDF
668.06 kB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/28071
Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 26
  • ???jsp.display-item.citation.isi??? 27
social impact