6A,6B-Dideox -6A,6B-di[(Ar-salicylidene)amino]-beta-cyclodextrin was synthesized and characterized by NMR, UV and CD spectroscopy in order to prepare a N,N'-bis-(salicylidene)ethane-1,2-diamine (SalenH(2)) type ligand. The manganese(III) complex was synthesized and characterized by UV and cyclic voltammetry and compared to EUK-8. The superoxide dismutase (SOD)-like and catalase-like activities were tested by indirect assay. The cyclodextrin complex shows a larger solubility than EUK-8 and good SOD-like activity. Catalase activity is also shown. (C) 2004 Elsevier Inc. All rights reserved.
Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity
VECCHIO, Graziella
2004-01-01
Abstract
6A,6B-Dideox -6A,6B-di[(Ar-salicylidene)amino]-beta-cyclodextrin was synthesized and characterized by NMR, UV and CD spectroscopy in order to prepare a N,N'-bis-(salicylidene)ethane-1,2-diamine (SalenH(2)) type ligand. The manganese(III) complex was synthesized and characterized by UV and cyclic voltammetry and compared to EUK-8. The superoxide dismutase (SOD)-like and catalase-like activities were tested by indirect assay. The cyclodextrin complex shows a larger solubility than EUK-8 and good SOD-like activity. Catalase activity is also shown. (C) 2004 Elsevier Inc. All rights reserved.File in questo prodotto:
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