Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity

Puglisi, A; Tabbi, G; Vecchio, Graziella

doi:10.1016/j.jinorgbio.2004.02.012

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6A,6B-Dideox -6A,6B-di[(Ar-salicylidene)amino]-beta-cyclodextrin was synthesized and characterized by NMR, UV and CD spectroscopy in order to prepare a N,N'-bis-(salicylidene)ethane-1,2-diamine (SalenH(2)) type ligand. The manganese(III) complex was synthesized and characterized by UV and cyclic voltammetry and compared to EUK-8. The superoxide dismutase (SOD)-like and catalase-like activities were tested by indirect assay. The cyclodextrin complex shows a larger solubility than EUK-8 and good SOD-like activity. Catalase activity is also shown. (C) 2004 Elsevier Inc. All rights reserved.

Titolo:	Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity
Autori interni:	Puglisi A Tabbi G VECCHIO, Graziella mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2004
Rivista:	JOURNAL OF INORGANIC BIOCHEMISTRY
Citazione:	Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity / Puglisi A; Tabbi G; Vecchio G. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 98:6(2004), pp. 969-976.
Abstract:	6A,6B-Dideox -6A,6B-di[(Ar-salicylidene)amino]-beta-cyclodextrin was synthesized and characterized by NMR, UV and CD spectroscopy in order to prepare a N,N'-bis-(salicylidene)ethane-1,2-diamine (SalenH(2)) type ligand. The manganese(III) complex was synthesized and characterized by UV and cyclic voltammetry and compared to EUK-8. The superoxide dismutase (SOD)-like and catalase-like activities were tested by indirect assay. The cyclodextrin complex shows a larger solubility than EUK-8 and good SOD-like activity. Catalase activity is also shown. (C) 2004 Elsevier Inc. All rights reserved.
Handle:	http://hdl.handle.net/20.500.11769/10041
Appare nelle tipologie:	1.1 Articolo in rivista

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