Functionalization at the NH group (s) of 1-amino-1-arylmethyl phosphonic acid diethyl esters with mono-isocyanates was performed in order to produce alkyl ureas bearing the phosphonate group. The condensation reaction is easily performed in dry toluene at 80 degrees C using a catalytic amount of Et(3)N, and the white crystalline products are obtained in satisfactory yields. Characterizations of these new compounds, of potential applications in agrochemistry, were performed by H-1-NMR spectroscopy and by MS-FAB spectrometry, which reveals the presence of very diagnostic signals or peaks for structural assignments.

Functionalization of 1-amino-1-arylmethyl phosphonic acid diethyl esters at the NH group

FAILLA, Salvatore;
1996

Abstract

Functionalization at the NH group (s) of 1-amino-1-arylmethyl phosphonic acid diethyl esters with mono-isocyanates was performed in order to produce alkyl ureas bearing the phosphonate group. The condensation reaction is easily performed in dry toluene at 80 degrees C using a catalytic amount of Et(3)N, and the white crystalline products are obtained in satisfactory yields. Characterizations of these new compounds, of potential applications in agrochemistry, were performed by H-1-NMR spectroscopy and by MS-FAB spectrometry, which reveals the presence of very diagnostic signals or peaks for structural assignments.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.11769/10362
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