Paclitaxel (PTX) was complexed with b-cyclodextrin (1), 2,6-dimethyl-b-cyclodextrin (2) and 2,3,6-trimethyl-b-cyclodextrin (3). PTX–CYD complexes were characterized both at the solid and liquid states. Experimental findings are in agreement with molecular modeling analysis, which showed different PTX–CYD interaction as a function of macrocyle methylation. The complexation of PTX within the CYD cavity preserved its antitumoral activity.
|Titolo:||Preparation, characterization, molecular modeling and in vitro activity of paclitaxel-cyclodextrin complexes|
|Data di pubblicazione:||2002|
|Citazione:||Preparation, characterization, molecular modeling and in vitro activity of paclitaxel-cyclodextrin complexes / Alcaro S; Ventura CA; Paolino D; Battaglia D; Ortuso F; Cattel L; Puglisi G; Fresta M. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 12:12(2002), pp. 1637-1641.|
|Appare nelle tipologie:||1.1 Articolo in rivista|