Paclitaxel (PTX) was complexed with b-cyclodextrin (1), 2,6-dimethyl-b-cyclodextrin (2) and 2,3,6-trimethyl-b-cyclodextrin(3). PTX–CYD complexes were characterized both at the solid and liquid states. Experimental findings are in agreementwith molecular modeling analysis, which showed different PTX–CYD interaction as a function of macrocyle methylation. Thecomplexation of PTX within the CYD cavity preserved its antitumoral activity.

Preparation, characterization, molecular modeling and in vitro activity of paclitaxel-cyclodextrin complexes

PUGLISI, Giovanni;
2002-01-01

Abstract

Paclitaxel (PTX) was complexed with b-cyclodextrin (1), 2,6-dimethyl-b-cyclodextrin (2) and 2,3,6-trimethyl-b-cyclodextrin(3). PTX–CYD complexes were characterized both at the solid and liquid states. Experimental findings are in agreementwith molecular modeling analysis, which showed different PTX–CYD interaction as a function of macrocyle methylation. Thecomplexation of PTX within the CYD cavity preserved its antitumoral activity.
File in questo prodotto:
File Dimensione Formato  
134.pdf

solo gestori archivio

Tipologia: Versione Editoriale (PDF)
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 182.69 kB
Formato Adobe PDF
182.69 kB Adobe PDF   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/10406
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 60
  • ???jsp.display-item.citation.isi??? 52
social impact