Paclitaxel (PTX) was complexed with b-cyclodextrin (1), 2,6-dimethyl-b-cyclodextrin (2) and 2,3,6-trimethyl-b-cyclodextrin (3). PTX–CYD complexes were characterized both at the solid and liquid states. Experimental findings are in agreement with molecular modeling analysis, which showed different PTX–CYD interaction as a function of macrocyle methylation. The complexation of PTX within the CYD cavity preserved its antitumoral activity.

Preparation, characterization, molecular modeling and in vitro activity of paclitaxel-cyclodextrin complexes

PUGLISI, Giovanni;
2002-01-01

Abstract

Paclitaxel (PTX) was complexed with b-cyclodextrin (1), 2,6-dimethyl-b-cyclodextrin (2) and 2,3,6-trimethyl-b-cyclodextrin (3). PTX–CYD complexes were characterized both at the solid and liquid states. Experimental findings are in agreement with molecular modeling analysis, which showed different PTX–CYD interaction as a function of macrocyle methylation. The complexation of PTX within the CYD cavity preserved its antitumoral activity.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.11769/10406
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