The influence of beta-cyclodextrin inclusion complexes with different anti-inflammatory agents on the main phase transition of dipalmitoylphosphatidylcholine vesicles was studied by differential scanning calorimetry. Drugs cause a lowering of the temperature of the gel to liquid crystal phase transition and a slight broadening of the calorimetric peak. Similar effects were found between the various free drugs, whereas noticeable differences were observed when drugs were employed as inclusion complexes. The ability of the inclusion complexes to act as drug carriers is discussed in terms of better release of drug with respect to the lipidic bilayer, chosen as model membrane. The interactions among inclusion complexes is explainable based on the values of their stability constants (K(c)).
|Titolo:||EFFECT OF THE COMPLEXATION OF SOME NONSTEROIDAL ANTIINFLAMMATORY DRUGS WITH BETA-CYCLODEXTRIN ON THE INTERACTION WITH PHOSPHATIDYLCHOLINE LIPOSOMES|
|Data di pubblicazione:||1992|
|Appare nelle tipologie:||1.1 Articolo in rivista|